Topical azelaic acid in the treatment of rosacea
Topical azelaic acid in the treatment of rosacea
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外用壬二酸治疗红斑痤疮
DOI：
10.3109/09546639309082150
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发表时间：
1993
影响因子：
2.9
通讯作者：
R. Zaumseil
中科院分区：
文献类型：
--
作者：
A. Carmichael;R. Marks;K. Graupe;R. Zaumseil
杜鹃酸现在是一种公认的治疗寻常痤疮的药物，其抗菌和溶解粉刺的活性是其有益效果的主要原因。在这份报告中，我们描述了一项单中心、双盲、对照、对侧分裂脸研究的结果，该研究观察了20%杜鹃酸乳膏对酒渣鼻患者的疗效。这项研究被设计为20%杜鹃酸乳膏制剂与其外观相同的安慰剂之间的随机半脸比较。患者接受超过9周的治疗，并在治疗结束后4周进行复查。两边的丘疹、脓疱疹和红斑都减少了，尽管改善的程度在杜鹃花酸处理的一侧更好。所使用的主观总体评价也是如此。没有记录到对毛细血管扩张的影响。在治疗的两个方面，轻微的皮肤刺激的记录几乎相等，尽管在前3周这是更明显的…
Azelaic acid is now an established therapeutic agent for acne vulgaris, where its antibacterial and comedolytic activity is responsible in the main for its beneficial effects. In this report we describe the results of a single-centre double-blind controlled contralateral split-face study of the effects of 20% azelaic acid cream in patients with rosacea. The study was designed as a randomized half-face comparison between a 20% azelaic acid cream preparation and its identical-appearing vehicle as placebo. Patients were treated over a 9-week period and reviewed 4 weeks after the end of the treatment period. Both ‘sides’ showed a reduction in papules, pustules and erythema, although the degree of improvement was superior on the azelaic acid-treated sides. This was also the case for the subjective overall evaluation used. No effect on telangiectasia was recorded. Minor degrees of skin irritation were recorded on both treatment sides in nearly equal numbers, although in the first 3 weeks this was more pronounce...