Mini Review Article
Mini Review Article
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通讯作者：
A. Tessitore;A. Giordano;R. De Micco;A. Russo;G. Tedeschi
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作者：
A. Tessitore;A. Giordano;R. De Micco;A. Russo;G. Tedeschi
帕金森病（PD）的诊断仍然是临床的;然而，在过去的几十年里，先进的MRI技术的快速发展已经使得有可能检测到帕金森病患者的结构和越来越多的功能性脑变化。的确，功能性磁共振成像（fMRI）技术可以直接测量帕金森病患者早期和复杂阶段的大脑活动和连通性，本文综述了近年来有关帕金森病患者感觉运动区活动和连通性的功能性磁共振成像（fMRI）研究报告，包括任务相关和静息态两种分析方法（fMRI）阐明PD晚期运动障碍并发症的潜在病理生理机制。
The diagnosis of Parkinson's disease (PD) remains still clinical; nevertheless, in the last decades, the rapid evolution of advanced MRI techniques has made it possible to detect structural and, increasingly, functional brain changes in patients with PD. Indeed, functional MRI (fMRI) techniques have offered the opportunity to directly measure the brain's activity and connectivity in patients with PD both in early and complicated stage of the disease.The aims of the following review are (1) to present an overview of recent fMRI reports investigating the activity and connectivity of sensorimotor areas in patients with PD using both task-related and " resting-state " fMRI analysis (2) to elucidate potential pathophysiological mechanisms underlying dyskinetic motor complications in the advanced stage of PD.