Exposure to Violence and Virologic and Immunological Outcomes Among Youth With Perinatal HIV in the Pediatric HIV/AIDS Cohort Study

Exposure to Violence and Virologic and Immunological Outcomes Among Youth With Perinatal HIV in the Pediatric HIV/AIDS Cohort Study
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DOI:
10.1016/j.jadohealth.2016.03.004
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发表时间:
2016-07-01
影响因子:
7.6
通讯作者:
Puga, Ana
Puga, Ana
中科院分区:
医学2区
文献类型:
--
作者:
Kacanek, Deborah;Malee, Kathleen;Puga, Ana

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目的:儿童时期遭受暴力与不良健康结果有关。关于青年和护理人员暴力暴露与围产期人类免疫缺陷病毒(HIV)感染(PHIV)青年临床结局的患病率和关系知之甚少。我们评估了青少年和照顾者暴力暴露与未抑制病毒载量(VL)的关系。儿科艾滋病毒/艾滋病队列研究青少年主方案中8至15岁PHIV参与者中(HIV RNA > 400拷贝/毫升)和CD 4%< 25%。方法:收集年度临床检查、记录摘要和访谈数据,包括青年人报告最近遭受暴力的情况和照顾者自我报告成年后受到攻击/虐待的情况。结果:在268例PHIV感染者中(53%为女孩,平均年龄12.8岁,21%为白色,42%为有家庭收入者),20%为无家庭收入者(20%为男性,20%为女性,20%为男性,20%为女性,20%为男性,20%为女性,20%为男性,20%为女性,20%为女性,20%为男性,20%为女性,20%为女性,20%为男性,20%为女性,20%为男性,20%为女性,20%为女性,20%为男性,20%为女性,20%为女性,20%为男性,20%为女性,20%为女性,20%为女性,20%为女性,20%为男性,20%为女性,20%为女性,20%为女性,20%为男性,20%为女性,
Purpose: Exposure to violence in childhood has been linked to adverse health outcomes. Little is known about the prevalence and relationship of youth and caregiver violence exposure to clinical outcomes among youth with perinatal human immunodeficiency virus (HIV) infection (PHIV). We evaluated associations of youth and caregiver violence exposure with unsuppressed viral load (VL) (HIV RNA > 400 copies/mL) and CD4% < 25% among 8- to 15-year-old participants with PHIV in the Pediatric HIV/AIDS Cohort Study Adolescent Master Protocol.Methods: Annual clinical examination, record abstraction, and interview data were collected, including youth report of recent exposure to violence and caregivers' self-report of being assaulted/abused in adulthood. Multivariable logistic regression methods were used to calculate adjusted odds ratios for unsuppressed VL and CD4% < 25%, controlling for sociodemographic characteristics.Results: Among 268 youth with PHIV (53% girls, mean age 12.8 years, 21% white, 42% with household income