Sialidase inhibitory activity of diarylnonanoid and neolignan compounds extracted from the seeds of Myristica fragrans.
Sialidase inhibitory activity of diarylnonanoid and neolignan compounds extracted from the seeds of Myristica fragrans.
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DOI：
10.1016/j.bmcl.2017.05.055
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发表时间：
2017-07
影响因子：
2.7
通讯作者：
Ji-Young Park;Su Hwan Lim;Bo Ram Kim;Hyung Jae Jeong;Hyung-Jun Kwon;G. Song;Young Bae Ryu;Woo Song Lee
中科院分区：
文献类型：
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作者：
Ji-Young Park;Su Hwan Lim;Bo Ram Kim;Hyung Jae Jeong;Hyung-Jun Kwon;G. Song;Young Bae Ryu;Woo Song Lee
唾液酸酶是关键的毒力因子，它将唾液酸从宿主细胞表面的多糖中移除，从而揭开受体的面纱，从而促进细菌的黏附和定植。在这项研究中，我们报道了从肉豆蔻种子中分离和鉴定新型肺炎链球菌唾液酸酶抑制剂NaA、NanB和Nanc的方法。在分离的化合物(1-12)中，马拉巴利酮C对肺炎链球菌唾液酸酶的抑制作用最强(NaNA的IC50值为0.3%μM，NanB的IC50值为3.6%μM，Nanc的IC50值为2.9%μM)。这些结果表明马拉巴利酮C和新木脂素类化合物可能是潜在的抗S药物。肺炎感染剂。
Sialidases are key virulence factors that remove sialic acid from host cell surface glycans, thus unmasking receptors to facilitate bacterial adherence and colonization. In this study, we report the isolation and characterization of novel inhibitors of theStreptococcus pneumoniaesialidases NanA, NanB, and NanC fromMyristica fragransseeds. Of the isolated compounds (1–12), malabaricone C showed the most pneumococcal sialidases inhibition (IC50of 0.3 μM for NanA, 3.6 μM for NanB, and 2.9 μM for NanC). These results suggested that malabaricone C and neolignans could be potential agents for combatingS. pneumoniaeinfection agents.