Body mass index and retinopathy in Asian populations with diabetes mellitus
Body mass index and retinopathy in Asian populations with diabetes mellitus
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DOI：
10.1007/s00592-014-0602-2
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发表时间：
2015-02-01
影响因子：
3.8
通讯作者：
Sabanayagam, Charumathi
中科院分区：
文献类型：
--
作者：
Rooney, David;Lye, Weng Kit;Sabanayagam, Charumathi
身体质量指数（BMI）是糖尿病的一个既定危险因素。然而，BMI和糖尿病视网膜病变（DR）之间的关联尚未确定。我们的目的是在新加坡多种族亚洲成年人的大样本人群中评估BMI与DR之间的关联。我们检查了2,278名年龄为千分之一日元40岁的糖尿病患者，他们参加了2004年至2011年进行的三项基于人群的研究：新加坡马来人眼科研究，新加坡印度人眼科研究和新加坡中国人眼科研究。采用改良的Airlie House分类法对双眼拍摄的视网膜照片进行任何和视力威胁（VTDR）分级。BMI（kg/m2）分为正常/体重不足（< 25）、超重（25-29.9）和肥胖（千分之一日元30）。研究人群中任何和VTDR的患病率分别为35.1%和9.1%。随着BMI类别的增加，any和VTDR的患病率降低（P趋势< 0.001和0.005）。在调整潜在混杂因素的多变量模型中，与体重正常的患者相比，超重和肥胖患者发生任何DR的比值比（95%置信区间）分别为0.71（0.57-0.88）和0.70（0.53-0.92）。超重和肥胖者相应的VTDR估计值分别为0.84（0.59-1.21）和0.58（0.35-0.94）。当BMI作为一个连续变量进行分析时，在按种族和年龄分层的分析中，BMI和任何DR之间的负相关性始终存在。在多种族亚洲成年人的人群样本中，BMI水平与任何DR和VTDR呈负相关。
Body mass index (BMI) is an established risk factor for diabetes. However, the association between BMI and diabetic retinopathy (DR) has been inconclusive. We aimed to assess the association between BMI and DR in a large population-based sample of multi-ethnic Asian adults in Singapore. We examined 2,278 adults aged a parts per thousand yen40 years with diabetes who participated in three population-based studies conducted from 2004 to 2011: the Singapore Malay Eye Study, the Singapore Indian Eye Study, and the Singapore Chinese Eye Study. Retinal photographs taken from both eyes were graded for any and vision-threatening (VTDR) using the modified Airlie House Classification. BMI (kg/m(2)) was categorized into normal/underweight (< 25), overweight (25-29.9), and obese (a parts per thousand yen30). The prevalence rates of any and VTDR in the study population were 35.1 % and 9.1 %, respectively. The prevalence of any and VTDR decreased with increasing categories of BMI (P trend < 0.001 and 0.005). In multivariable models adjusted for potential confounders, compared to those with normal weight, the odds ratio (95 % confidence interval) of any DR was 0.71 (0.57-0.88) for overweight and 0.70 (0.53-0.92) for obese. Corresponding estimates for VTDR were 0.84 (0.59-1.21) for overweight and 0.58 (0.35-0.94) for obese. The inverse association between BMI and any DR was consistently present when BMI was analyzed as a continuous variable and in analyses stratified by ethnicity and age. In a population-based sample of multi-ethnic Asian adults, BMI levels were inversely associated with any DR and VTDR.