The use of nano-computed tomography to enhance musculoskeletal research.
The use of nano-computed tomography to enhance musculoskeletal research.
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DOI：
10.3109/03008207.2015.1005211
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发表时间：
2015-04
影响因子：
2.9
通讯作者：
Jepsen KJ
中科院分区：
文献类型：
--
作者：
Khoury BM;Bigelow EM;Smith LM;Schlecht SH;Scheller EL;Andarawis-Puri N;Jepsen KJ
计算机断层扫描（CT）成像的进展正在为更精确地表征和量化结缔组织微结构开辟新的途径。在过去的二十年中，微计算机断层扫描（microCT）显着增强了破坏性的方法，主要是在骨研究领域的组织结构的三维微观分析。最近，microCT已经与造影剂结合使用，以生成由于其天然放射密度而难以可视化的软组织的对比度增强图像。CT技术的最新进展已经通过利用更强大的纳米聚焦X射线源（诸如在纳米计算机断层摄影（nanoCT）系统中发现的纳米聚焦X射线源）实现了超高分辨率成像。NanoCT成像通过减少采集时间和显着扩大可以在大小，年龄和组织类型（骨骼，肌肉，肌腱，软骨，血管和脂肪组织）方面成像的样本范围，促进了肌肉骨骼研究的扩展。我们介绍了nanoCT成像在各种组织类型中的应用和早期结果，以及这种超高分辨率成像方式如何能够以以前不可能的细节水平表征微观结构。对比度增强成像技术，使软组织可视化和表征也概述。
Advances in computed tomography (CT) imaging are opening new avenues toward more precise characterization and quantification of connective tissue microarchitecture. In the last two decades, micro-computed tomography (microCT) has significantly augmented destructive methods for the 3D micro-analysis of tissue structure, primarily in the bone research field. Recently, microCT has been employed in combination with contrast agents to generate contrast-enhanced images of soft tissues that are otherwise difficult to visualize due to their native radiodensity. More recent advances in CT technology have enabled ultra-high resolution imaging by utilizing a more powerful nano-focused X-ray source, such as that found in nano-computed tomography (nanoCT) systems. NanoCT imaging has facilitated the expansion of musculoskeletal research by reducing acquisition time and significantly expanding the range of samples that can be imaged in terms of size, age and tissue-type (bone, muscle, tendon, cartilage, vessels and adipose tissue). We present the application and early results of nanoCT imaging in various tissue types and how this ultra-high resolution imaging modality is capable of characterizing microstructures at levels of details previously not possible. Contrast-enhanced imaging techniques to enable soft-tissue visualization and characterization are also outlined.