[Interferon therapy of chronic hepatitis].
[Interferon therapy of chronic hepatitis].
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发表时间：
1992-08
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通讯作者：
Shiro Iino
中科院分区：
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作者：
Shiro Iino
本文综述了日本干扰素（IFN）治疗慢性B和C型肝炎的现状。IFN的施用导致2 - 5 '寡腺苷酸合成酶（2-5AS）的诱导。2-5AS产生能够激活降解病毒RNA的潜在RNA酶的2-5A。在慢性B型肝炎患者中，当使用IFN时，观察到HBV DNA、HBe抗原和HBs抗原的显著降低。然而，HBV的复制在IFN给药停止后再次开始，因为IFN的作用不影响作为复制起点的HBV DNA。另一方面，HCV是RNA病毒，IFN不仅抑制HCV蛋白及其前基因组的产生，而且还根除作为复制起点的HCV RNA。在约40%的慢性丙型肝炎患者中，在最满意的方案下，IFN治疗后ALT持续正常化和HCV RNA阴性。
The current state of interferon (IFN) therapy for chronic hepatitis B and C in Japan is reviewed. The administration of IFN results in induction of 2'-5' oligoadenylate synthetase (2-5AS). 2-5AS produces 2-5A capable of activating a latent RNAase that degrades viral RNA. In patient with chronic hepatitis B, prominent reduction of HBV DNA, HBe antigen and HBs antigens is observed, when IFN is administered. However, the replication of HBV starts again after stopping of IFN administration, because the effects of IFN do not affect HBV DNA which is the origin of replication. On the other hand, HCV is a RNA virus IFN not only suppresses the production of HCV proteins and its pregenome, but also eradicate HCV RNA that is the origin of replication. In around 40% of the patients with chronic hepatitis C, sustained normalization of ALT and negativity of HCV RNA was obtained after IFN therapy under the most satisfactory regimen.