Fetal cell-free DNA fraction in maternal plasma for the prediction of hypertensive disorders of pregnancy
Fetal cell-free DNA fraction in maternal plasma for the prediction of hypertensive disorders of pregnancy
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DOI：
10.1016/j.ejogrb.2018.03.048
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发表时间：
2018-05-01
影响因子：
2.6
通讯作者：
Sago, Haruhiko
中科院分区：
文献类型：
--
作者：
Suzumori, Nobuhiro;Sekizawa, Akihiko;Sago, Haruhiko
目的：本研究的目的是根据胎龄和母亲特征比较单胎妊娠无创产前检测（NIPT）期间的胎儿分数，以评估该参数在预测妊娠期糖尿病（GDM）和妊娠期高血压疾病（HDP）等妊娠并发症中的效用。 研究设计：本研究是一项多中心前瞻性队列研究。目前的数据是从 NIPT 结果呈阴性的女性中收集的。评估胎儿分数与胎龄、母亲体重和身高、流产、早产以及妊娠并发症（包括 GDM、HDP 和胎盘早剥）发生率之间的关系。 结果：本研究共登记了 5582 名 NIPT 阴性结果的孕妇。对研究人群的人口特征进行了统计分析，发现患有 HDP 的女性在妊娠早期采集的样本中胎儿比例往往较低。对于患有 HDP 的女性，受试者工作特征曲线 (ROC) 分析中的曲线下面积 (AUC) 为 0.608。 结论：NIPT 上胎儿分数较低可能与未来的 HDP 相关。然而，预测胎儿比例较低的女性在妊娠早期的 HDP 可能很困难。 (C)2018 Elsevier B.V 版权所有。
Objective: The purpose of this study is to compare the fetal fractions during non-invasive prenatal testing (NIPT) in singleton pregnancies according to gestational age and maternal characteristics to evaluate the utility of this parameter for the prediction of pregnancy complications including gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP).Study design: This study was a multicenter prospective cohort study. The present data were collected from women whose NIPT results were negative. The relationships between the fetal fractions and the gestational age, maternal weight and height, and incidences of miscarriage, preterm delivery, and pregnancy complications including GDM, HDP and placental abruption were assessed.Results: A total of 5582 pregnant women with verified NIPT negative results were registered in the study. The demographic characteristics of the study populations were statistically analyzed, and the women with HDP tended to have a low fetal fraction in samples taken during early gestation. The area under the curve (AUC) in a receiver operating characteristic curve (ROC) analysis was 0.608 for women with HDP.Conclusion: A low fetal fraction on NIPT might be correlated with future HDP. However, predicting HDP during early pregnancy in women with a low fetal fraction might be difficult. (C)2018 Elsevier B.V All rights reserved.