Organ-on-a-Chip: New Platform for Biological Analysis.
Organ-on-a-Chip: New Platform for Biological Analysis.
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DOI：
10.4137/aci.s28905
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Luo Y
中科院分区：
文献类型：
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作者：
An F;Qu Y;Liu X;Zhong R;Luo Y
对生理微环境中的生物分子和细胞进行直接检测和分析是生物学和药学快速评价的迫切需要。在过去的几年里，基于微流控装置的多功能体外器官和组织模型得到了显著的发展机遇，被称为“器官芯片”。简而言之，以哺乳动物细胞共培养和微通道网络创造的人工微环境为特征，是重建组织器官生理功能的一项很有前途的技术。本文综述了心脏、血管、肝脏、神经元、肾脏和多器官芯片的研究进展，并讨论了一些值得关注的潜在芯片检测方案。
Direct detection and analysis of biomolecules and cells in physiological microenvironment is urgently needed for fast evaluation of biology and pharmacy. The past several years have witnessed remarkable development opportunities in vitro organs and tissues models with multiple functions based on microfluidic devices, termed as “organ-on-a-chip”. Briefly speaking, it is a promising technology in rebuilding physiological functions of tissues and organs, featuring mammalian cell co-culture and artificial microenvironment created by microchannel networks. In this review, we summarized the advances in studies of heart-, vessel-, liver-, neuron-, kidney- and Multi-organs-on-a-chip, and discussed some noteworthy potential on-chip detection schemes.