Efficacy of Different Hemostatic Devices for Severe Liver Bleeding: A Randomized Controlled Animal Study
Efficacy of Different Hemostatic Devices for Severe Liver Bleeding: A Randomized Controlled Animal Study
复制标题
DOI：
10.1177/1553350610384405
复制
发表时间：
2010-12-01
影响因子：
1.5
通讯作者：
Weber, Gyoergy
中科院分区：
文献类型：
--
作者：
Takacs, Ildiko;Wegmann, Juergen;Weber, Gyoergy
背景在肝脏手术中，由于渗血的存在，很难做到正确止血。本研究的目的是比较新型止血敷布与2种市售止血敷布的潜在受益。方法.研究了基于胶原和纤维素的止血剂。通过以随机顺序应用不同的止血剂治疗标准化切除术，并测量出血时间。21天后进行肝脏肉眼评价和组织取样用于组织学研究。结果牛胶原蛋白（BoCo）、蛋白包被的马胶原蛋白（PECo）和氧化纤维素（OxCe）的出血时间分别为140 +/- 88、243 +/- 140（P = .005 vs BoCo）和352 +/- 70 s（P < .001 vs BoCo）。PECo的显微镜评价显示植入区出现纤维化和明显炎症，而BoCo和OxCe仅引起伤口区域纤维化。结论BoCo的止血效果明显优于PECo和OxCe。
Background. Correct hemostasis in liver surgery is hard to achieve because of the oozing bleeding. The aim of this study was to compare the potential benefits of a new compress to the 2 commercial hemostatic compresses. Methods. Collagen-and cellulose-based hemostatics were investigated. A standardized resection was treated by applying different hemostatics in a randomized order, and bleeding times were measured. Macroscopic evaluation of the liver and tissue sampling for histological investigations were carried out after 21 days. Results. The bleeding times of bovine collagen (BoCo), protein-coated equine collagen (PECo), and oxidized cellulose (OxCe) were 140 +/- 88, 243 +/- 140 (P = .005 vs BoCo), and 352 +/- 70 s (P < .001 vs BoCo), respectively. Microscopic evaluation of the PECo presented fibrosis and significant inflammation in the implantation zone, whereas BoCo and OxCe caused only fibrosis in the wound area. Conclusion. BoCo showed significantly better hemostatic effect than PECo and OxCe.