Coupled and reduced dimensional modeling of respiratory mechanics during spontaneous breathing
Coupled and reduced dimensional modeling of respiratory mechanics during spontaneous breathing
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DOI：
10.1002/cnm.2577
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发表时间：
2013-11-01
影响因子：
2.1
通讯作者：
Wall, W. A.
中科院分区：
文献类型：
--
作者：
Ismail, M.;Comerford, A.;Wall, W. A.
在本文中，我们开发了一个基于 0D 气道树和腺泡模型的全肺模型，用于研究自主呼吸期间的呼吸力学。该模型利用基于计算机断层扫描的几何结构和人工生成的肺叶填充气道树来模拟肺部的整个传导区域。除了传导气道之外，我们还开发了一个腺泡模型，该模型考虑了肺泡组织阻力、顺应性和胸膜内压力。通过这种方法，我们比较了四种不同的气道力学 0D 模型，并根据与传导气道 3D-0D 耦合模型的比较确定最佳模型；这种方法是可行的，因为大部分气道阻力仅限于较低的代，即气管和最初的几个支气管代。作为该模型的一个示例应用，我们模拟了自主呼吸条件下的流量和压力动态，即纯粹由胸膜腔压力驱动的流量条件。结果在定性和定量上都与报告的生理值非常一致。该模型的主要优点之一是能够深入了解周围区域的肺通气情况。这通常至关重要，因为这是需要信息，特别是用于研究疾病和气体交换的信息。因此，该模型可以用作更好地理解局部外周肺力学的工具，而不排除肺的上部。该工具还可用于健康和疾病中肺力学的体外研究。版权所有 (c) 2013 John Wiley & Sons, Ltd.
In this paper, we develop a total lung model based on a tree of 0D airway and acinar models for studying respiratory mechanics during spontaneous breathing. This model utilizes both computer tomography-based geometries and artificially generated lobe-filling airway trees to model the entire conducting region of the lung. Beyond the conducting airways, we develop an acinar model, which takes into account the alveolar tissue resistance, compliance, and the intrapleural pressure. With this methodology, we compare four different 0D models of airway mechanics and determine the best model based on a comparison with a 3D-0D coupled model of the conducting airways; this methodology is possible because the majority of airway resistance is confined to the lower generations, that is, the trachea and the first few bronchial generations. As an example application of the model, we simulate the flow and pressure dynamics under spontaneous breathing conditions, that is, at flow conditions driven purely by pleural space pressure. The results show good agreement, both qualitatively and quantitatively, with reported physiological values. One of the key advantages of this model is the ability to provide insight into lung ventilation in the peripheral regions. This is often crucial because this is where information, specifically for studying diseases and gas exchange, is needed. Thus, the model can be used as a tool for better understanding local peripheral lung mechanics without excluding the upper portions of the lung. This tool will be also useful for in vitro investigations of lung mechanics in both health and disease.Copyright (c) 2013 John Wiley & Sons, Ltd.