The role of follicular T helper cells in the onset and treatment of type 1 diabetes
The role of follicular T helper cells in the onset and treatment of type 1 diabetes
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滤泡辅助 T 细胞在 1 型糖尿病发病和治疗中的作用
DOI：
10.1016/j.intimp.2020.106499
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发表时间：
2020
影响因子：
5.6
通讯作者：
Wei Yang
中科院分区：
文献类型：
--
作者：
Xueyang Zou;Shuang Wang;Yi Zhang;Xiaoya Wang;Wei Yang
滤泡辅助性T细胞(TFH)是一种独特的CD4+T细胞亚群。它们的主要功能是参与生发中心(GC)的形成，并帮助B细胞产生抗体参与体液免疫反应。TFH细胞调节失调可导致多种自身免疫性疾病，如1型糖尿病(T1 DM)、系统性红斑狼疮(SLE)和类风湿关节炎。其中，T1 DM通常伴有高水平的自身抗体，如胰岛素抗体(IAA)和谷氨酸脱羧酶65抗体(GAD65Ab)。这些自身抗体的产生与体内TFH细胞的产生和激活密切相关，从而促进了T1 DM的发生发展。因此，本文将就TFH细胞与T1 DM的关系及其可能影响疾病的机制进行综述，并总结目前靶向TFH细胞治疗T1 DM的策略。
Follicular T helper (TFH) cells are a unique subset of CD4+T cells. Their main function is to participate in the formation of germinal centres (GC) and help B cells produce antibodies for involvement in humoral immune responses. TFH cell dysregulation can cause various autoimmune diseases, such as type 1 diabetes mellitus (T1DM), systemic lupus erythaematosus (SLE) and rheumatoid arthritis. Among them, T1DM is usually accompanied by high levels of autoantibodies, such as insulin antibody (IAA) and glutamate decarboxylase 65 antibody (GAD65Ab). The production of these autoantibodies is closely related to the production and activation of TFH cells in vivo, which promotes the development of T1DM. Therefore, this review will focus on the relationship between TFH cells and T1DM and the possible mechanisms that affect the disease and summarize the current strategies for targeting TFH cells in the treatment of T1DM.