Neutrophil-to-Lymphocyte Ratio as a Prognostic Indicator in Patients With Unresectable Gastric Cancer
Neutrophil-to-Lymphocyte Ratio as a Prognostic Indicator in Patients With Unresectable Gastric Cancer
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DOI：
10.21873/anticanres.13381
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发表时间：
2019-05-01
影响因子：
2
通讯作者：
Fujiwara, Yoshiyuki
中科院分区：
文献类型：
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作者：
Murakami, Yuki;Saito, Hiroaki;Fujiwara, Yoshiyuki
背景/目的：虽然许多可切除胃癌（GC）的预后指标已被确定，但不可切除胃癌（urGC）的预后指标尚未得到广泛研究。本研究的目的是探讨可通过常规血液检查确定的泌尿系癌患者预后指标。患者与方法：回顾性分析92例不能切除的晚期复发胃腺癌的临床病理因素。结果：基于患者工作曲线分析，中性粒细胞与淋巴细胞比值（NLR）在urGC患者1年生存率曲线下面积最高。在urGC患者中，晚期疾病患者的NLR明显高于复发疾病患者（p=0.0051）；有腹膜转移者与无腹膜转移者比较（p=0.041）。患者分为NLRHigh组（NLR bb0 = 2.83）和NLRLow组（NLR）
Background/Aim: Although many prognostic indicators have been identified for resectable gastric cancer (GC), prognostic indicators for unresectable GC (urGC) have not been widely studied. The aim of the current study was to investigate prognostic indicators that could be determined through routine blood examinations in patients with urGC. Patients and Methods: We retrospectively analyzed clinicopathological factors in 92 patients with unresectable advanced and recurrent gastric adenocarcinoma. Results: Based on receiver operating curve analysis, neutrophil-to-lymphocyte ratio (NLR) had the highest area under curve for 1-year survival among patients with urGC. Among patients with urGC, NLR was significantly higher in those with advanced disease compared to those with recurrent disease (p=0.0051); and in those with peritoneal metastasis compared to those without peritoneal metastasis (p=0.041). Patients were divided into NLRHigh (NLR >= 2.83) and NLRLow (NLR