The relationship between usual coffee consumption and serum C-reactive protein level in a Japanese female population
The relationship between usual coffee consumption and serum C-reactive protein level in a Japanese female population
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DOI：
10.1515/cclm.2008.286
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发表时间：
2008-10-01
影响因子：
6.8
通讯作者：
Sakane, Naoki
中科院分区：
文献类型：
--
作者：
Kotani, Kazuhiko;Tsuzaki, Kokoro;Sakane, Naoki
背景：饮用咖啡可降低胰岛素抵抗和2型糖尿病的发病率，并降低心血管疾病的风险。作为一种机制，可以考虑咖啡诱导的C反应蛋白（CRP）水平降低，这是这些疾病发展的标志。咖啡消费量和CRP之间的关联应建立在不同人群的研究，但在日本人，谁不一定每天消耗尽可能多的咖啡，是limited.Methods：共459个社区生活的日本妇女，年龄在23-83岁，进行了调查。临床数据包括年龄、体重指数、血压、HbA（1c）、血清高敏C反应蛋白（hsCRP）和生活习惯，如咖啡摄入量，均纳入分析。所有分析均在两组人群中进行，即，年龄< 60 and >= 60岁。结果：在< 60岁（p=0.001）和>= 60岁（p <0.0001）的相应组中，观察到>= 1杯/天组的hsCRP水平显著低于< 1杯/天组。在多元回归分析中，在< 60岁的各组中，咖啡消耗量与log hsCRP显著、独立和负相关（p=0.017）和≥ 60岁（p=0.0001）.结论：值得注意的是，在日本女性中证实了饮用咖啡（即使>= 1杯/天）对血清hsCRP水平的益处，与其他种族数据类似。
Background: Usual coffee consumption may decrease insulin resistance and type 2 diabetes incidence, and reduce cardiovascular disease risk. As a mechanism, coffee-induced lower levels of C-reactive protein (CRP), a marker for the development of these diseases, can be considered. The associations between coffee consumption and CRP should be established by studies on various populations, yet studies in Japanese people, who do not necessarily consume as much coffee daily, are limited.Methods: In total, 459 community-living Japanese women, aged 23-83 years, were investigated. Clinical data including age, body mass index, blood pressure, HbA(1c), serum high sensitive CRP (hsCRP) and lifestyle habits, such as coffee consumption, were included in the analyses. All analyses were performed in two groups of the population, i.e., age < 60 and >= 60 years.Results: Significantly lower levels of hsCRP were observed in the group of >= 1 cup/day than in that of < 1 cup/day in the respective groups of < 60 years (p=0.001) and >= 60 years (p < 0.0001). In multiple regression analysis, coffee consumption was significantly, independently and inversely correlated to log-hsCRP in the respective groups of < 60 years (p=0.017) and >= 60 years (p=0.0001).Conclusions: It was noteworthy that the benefits of coffee consumption, even if >= 1 cup/day, on serum hsCRP levels were confirmed in Japanese women, following similarly to other ethnic data.