Hsa-miR-181a-5p Expression and Effects on Cell Proliferation in Gastric Cancer
Hsa-miR-181a-5p Expression and Effects on Cell Proliferation in Gastric Cancer
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DOI：
10.7314/apjcp.2013.14.6.3871
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发表时间：
2013-01-01
影响因子：
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通讯作者：
Zhou, Rong-Ping
中科院分区：
文献类型：
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作者：
Chen, Gang;Shen, Zhi-Li;Zhou, Rong-Ping
目的：microRNAs（miRNAs）是一类内源性非编码单链小RNA（约22 nt）。越来越多的证据表明，miRNA的异常表达与胃癌的发生、发展密切相关。材料与方法：通过qRT-PCR评估GC组织和细胞系中miR-181 a-5 p的表达水平，并测试其与临床特征的相关性。此外，研究了miR-181 a-5 p对GC细胞生长的影响。结果：胃癌组织中miR-181 a-5 p表达上调，与淋巴结、神经和血管浸润密切相关（P
Purpose: MicroRNAs (miRNAs) are small endogenous, non-coding, single-stranded RNAs (approximately 22 nt). Accumulating evidence has shown that aberrant miRNA expression is pronounced and correlated with gastric cancer genesis and progression. Materials and Methods: Expression levels of miR-181a-5p in GC tissues and cell lines were assessed by qRT-PCR and tested for correlation with clinical features. In addition, effects of miR-181a-5p on GC cell growth were investigated. Results: Our findings indicate that miR-181a-5p is upregulated in GC, in correlation with lymph node invasion, nerve invasion and vascular invasion (P