Air Pollution and Preterm Premature Rupture of Membranes: A Spatiotemporal Analysis
Air Pollution and Preterm Premature Rupture of Membranes: A Spatiotemporal Analysis
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DOI：
10.1093/aje/kwt240
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发表时间：
2014-01-15
影响因子：
5
通讯作者：
Nieuwenhuijsen, Mark J.
中科院分区：
文献类型：
--
作者：
Dadvand, Payam;Basagana, Xavier;Nieuwenhuijsen, Mark J.
早产胎膜早破（PROM）是早产的主要可识别诱发因素。尽管母亲接触空气污染可能会对早产胎膜早破产生影响，但没有证据表明这种影响。在这项研究中，基于西班牙巴塞罗那 (20022005) 发生的 5,555 名单胎出生，我们调查了母亲接触二氧化氮、氮氧化物和空气动力学直径为 2.5 m (PM2.5)、2.5 m10 m 和 10 m 的颗粒物以及 PM2.5 光吸收与早产胎膜早破和胎膜破裂时胎龄 (ROM) 的关系。我们利用时间调整的土地使用回归模型来预测每个受试者在怀孕期间每周家庭住址的污染物水平。我们进行了匹配（根据暴露时间长短）病例对照分析，以估计整个妊娠期间和 ROM 前最后 3 个月期间暴露水平增加 1 个四分位数范围相关的早产 PROM 风险。我们发现，早产 PROM 风险增加高达 50（95 置信区间：4, 116），ROM 孕龄减少 1.3 天（95 置信区间：1.9, 0.6），与整个怀孕期间和 ROM 前最后 3 个月的 PM2.5 吸光度、二氧化氮暴露和氮氧化物暴露相关。
Preterm premature rupture of membranes (PROM) is the leading identifiable predisposing factor for preterm birth. Although maternal exposure to air pollution can potentially have an impact on preterm PROM, there is no available evidence on such an impact. In this study, based on 5,555 singleton births occurring in Barcelona, Spain (20022005), we investigated the associations of maternal exposure to nitrogen dioxide, nitrogen oxides, and particulate matter with aerodynamic diameters of 2.5 m (PM2.5), 2.5 m10 m, and 10 m and PM2.5 light absorption with preterm PROM and gestational age at the rupture of membranes (ROM). We utilized temporally adjusted land-use regression models to predict pollutant levels at each subjects home address during each week of her pregnancy. We conducted matched (according to the length of exposure) case-control analyses to estimate the preterm PROM risk associated with 1 interquartile-range increase in exposure levels during the entire pregnancy and during the last 3 months prior to ROM. We found an increase in preterm PROM risk of up to 50 (95 confidence interval: 4, 116) and a 1.3-day (95 confidence interval: 1.9, 0.6) reduction in gestational age at ROM associated with PM2.5 absorbance, nitrogen dioxide exposure, and nitrogen oxide exposure during the entire pregnancy and the last 3 months prior to ROM.