Annonamine, a New Aporphine Alkaloid from the Leaves of Annona muricata
Annonamine, a New Aporphine Alkaloid from the Leaves of Annona muricata
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DOI：
10.1248/cpb.60.257
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发表时间：
2012-02-01
影响因子：
1.7
通讯作者：
Takeda, Yoshio
中科院分区：
文献类型：
--
作者：
Matsushige, Ayano;Kotake, Yaichiro;Takeda, Yoshio
加勒比岛屿瓜德罗普岛的非典型帕金森症被认为与食用番荔枝科植物有关，尤其是番荔枝（刺果番荔枝）。在这项研究中，从 A. muricata L. 的叶子中分离出了一种名为 annonamine (1) 的新阿朴啡生物碱以及四种已知的苄基异喹啉生物碱 (2-5)。通过光谱方法阐明了分离化合物的结构。
Atypical Parkinsonism in the Caribbean Island Guadeloupe is thought to be associated with the consumption of plants of the Annonaceae family, especially Annona maricata (soursop). In this study, a new aporphine alkaloid named annonamine (1) was isolated from the leaves of A. muricata L. together with four known benzylisoquinoline alkaloids (2-5). The structures of the isolated compounds were elucidated by the spectroscopic method.