Parental decline of pneumococcal vaccination and risk of pneumococcal related disease in children
Parental decline of pneumococcal vaccination and risk of pneumococcal related disease in children
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DOI：
10.1016/j.vaccine.2010.11.085
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发表时间：
2011-01-29
期刊：
影响因子：
5.5
通讯作者：
Hambidge, Simon J.
中科院分区：
文献类型：
--
作者：
Glanz, Jason M.;McClure, David L.;Hambidge, Simon J.
背景：越来越多的父母选择拒绝给孩子接种疫苗。本研究探讨了父母决定不接种肺炎球菌结合疫苗（PCV7）与儿童因肺炎球菌疾病或大叶性肺炎住院的风险之间的关系。方法：我们在2004年至2009年期间加入凯撒永久科罗拉多州（KPCO）健康计划的儿童队列中进行了一项病例对照研究。每个因肺炎球菌病或大叶性肺炎住院的儿童（n = 106）与4个随机选择的对照组（n = 401）相匹配。病例按年龄、性别、高危状态、日历时间和KPCO登记时间与对照组相匹配。疾病状况和父母接种疫苗的决定通过医疗记录审查得到验证。病例和对照组被分为疫苗减少组和疫苗接受组。结果：106例病例中有6例（6%）PCV7疫苗下降；在401例对照中，有4例（1%）疫苗接种下降。父母拒绝接种PCV7疫苗的儿童因侵袭性肺炎球菌病或大叶性肺炎住院的可能性是接种疫苗儿童的6.5倍（OR = 6.5; 95% CI = 1.7, 24.5）。结论：父母少接种肺炎球菌疫苗明显增加了儿童因肺炎球菌病或大叶性肺炎住院的风险。服务提供者可以利用这些信息帮助父母权衡给孩子接种疫苗的好处和风险。(C) 2010 Elsevier Ltd.版权所有。
Background: An increasing number of parents are choosing to decline immunizations for their children. This study examined the association between the parental decision to decline pneumococcal conjugate (PCV7) vaccinations and the risk of hospitalization due to pneumococcal disease or lobar pneumonia in children.Methods: We conducted a case-control study nested within a cohort of children enrolled in the Kaiser Permanente Colorado (KPCO) health plan between 2004 and 2009. Each child hospitalized with pneumococcal disease or lobar pneumonia (n = 106) was matched to 4 randomly selected controls (n = 401). Cases were matched to controls by age, sex, high-risk status, calendar time, and length of enrollment in KPCO. Disease status and parental vaccination decisions were validated with medical record review. Cases and controls were classified as vaccine decliners or vaccine acceptors.Results: Among 106 cases, there were 6 (6%) PCV7 vaccine decliners; among 401 controls, there were 4 (1%) vaccine decliners. Children of parents who declined PCV7 immunization were 6.5 times (OR = 6.5; 95% CI = 1.7, 24.5) more likely to be hospitalized for invasive pneumococcal disease or lobar pneumonia than vaccinated children.Conclusions: Parental decline of pneumococcal vaccination apparently increases the risk for hospitalization due to pneumococcal disease or lobar pneumonia in children. Providers can use this information when helping parents weigh the benefits and risks of immunizing their children. (C) 2010 Elsevier Ltd. All rights reserved.