In vivo brain viscoelastic properties measured by magnetic resonance elastography
In vivo brain viscoelastic properties measured by magnetic resonance elastography
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DOI：
10.1002/nbm.1254
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发表时间：
2008-08-01
影响因子：
2.9
通讯作者：
Sinkus, Ralph
中科院分区：
文献类型：
--
作者：
Green, Michael A.;Bilston, Lynne E.;Sinkus, Ralph
磁共振弹性成像（MRE）是一种非侵入性成像技术，用于可视化和量化组织的机械特性，提供超出目前标准MR序列所能获得的信息，例如，可以提供对大脑病理过程的新见解。本研究使用MIRE技术在3T下提取活体脑组织的复剪切模量，利用其全三维方法进行重建，通过应用卷曲算子去除反射波的贡献。校准的体模用于基准MIRE测量，并在体内结果健康志愿者。结果提供了体内脑储能模量（G '）的数据，发现灰质（3.1kPa）比白色物质（2.7kPa）显著更硬。第一次体内损耗模量（G“）测量显示灰质（2.5 kPa）和白色物质（2.5 kPa）之间没有显著差异。版权所有（C）2008约翰威利父子有限公司
Magnetic resonance elastography (MRE) is a non-invasive imaging technique used to visualise and quantify mechanical properties of tissue, providing information beyond what can be currently achieved with standard MR sequences and could, for instance, provide new insight into pathological processes in the brain. This Study uses the MIRE technique at 3 T to extract the complex shear modulus for in vivo brain tissue utilizing it full three-dimensional approach to reconstruction, removing contributions of the dilatational wave by application of the curl operator. A calibrated phantom is used to benchmark the MIRE measurements, and in vivo results are presented for healthy volunteers. The results provide data for in vivo brain storage modulus (G '), finding grey matter (3.1 kPa) to be significantly stiffer than white matter (2.7 kPa). The first in vivo loss modulus (G '') measurements show no significant difference between grey matter (2.5 kPa) and white matter (2.5 kPa). Copyright (C) 2008 John Wiley & Sons, Ltd.