Reprogramming the conduction system: Onward toward a biological pacemaker.
Reprogramming the conduction system: Onward toward a biological pacemaker.
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DOI：
10.1016/j.tcm.2015.03.015
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发表时间：
2016-01
影响因子：
9.3
通讯作者：
Rentschler S
中科院分区：
文献类型：
--
作者：
Meyers JD;Jay PY;Rentschler S
心脏传导系统的疾病可以使人衰弱和致命。电子起搏器在治疗窦和房室结功能障碍方面非常有效，但仍存在重要的局限性和并发症。这些问题推动了对生物起搏器开发的兴趣。在这里，我们回顾了动物模型的实验进展，并讨论了未来的方向，重点是重新编程心脏中的内源性细胞，以治疗心律和传导缺陷。
Diseases of the cardiac conduction system can be debilitating and deadly. Electronic pacemakers are incredibly effective in the treatment of sinus and AV node dysfunction, yet there remain important limitations and complications. These issues have driven interest in the development of a biological pacemaker. Here, we review experimental progress in animal models and discuss future directions, with a focus on reprogramming endogenous cells in the heart to treat defects of rhythm and conduction.
影响因子：
2.5
作者：
Gazit AZ;Li A;Choi JS;Miquerol L;Jay PY
通讯作者：
Jay PY