Chemical constituents of Cyrtomium fortumei (J.) Smith
Chemical constituents of Cyrtomium fortumei (J.) Smith
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DOI：
10.1080/14786419.2013.824442
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发表时间：
2013-11
影响因子：
2.2
通讯作者：
Shengjie Yang;Mingchuan Liu;Na Liang;Hongmei Xiang;Song-Song Yang-Song
中科院分区：
文献类型：
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作者：
Shengjie Yang;Mingchuan Liu;Na Liang;Hongmei Xiang;Song-Song Yang-Song
从贯众（Cyrtomium fortumei（J.）史密斯化合物1-5为首次从该属植物中分离得到，并通过3-（4，5-二甲基噻唑-2-基）-2，5-二苯基四唑溴化物测定法对所有化合物进行了体外抗一组人癌细胞的评价。其中化合物3和化合物4表现出明显的细胞毒活性，对MGC-803细胞的IC 50值分别为15.2和18.3 μg/mL。
Five known compounds, 6′-methylglucuronide-5-hydroxy-chromone (1), ethyl α-d-glactopyranoside (2), neoechinulin A (3), 9,12,13-trihydroxyoctadeca-10(E),15(Z)-dienoic acid (4) and phellopterin (5), were isolated from water extract of Cyrtomium fortumei (J.) Smith. Compounds 1–5 were isolated from this genus for the first time, and all the compounds were evaluated in vitro against a panel of human cancer cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Among them, compounds 3 and 4 exhibited significant cytotoxic activities, with IC50 values of 15.2 and 18.3 μg/mL on MGC-803 cells, respectively.