Epigenetic Associations between lncRNA/circRNA and miRNA in Hepatocellular Carcinoma.
Epigenetic Associations between lncRNA/circRNA and miRNA in Hepatocellular Carcinoma.
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DOI：
10.3390/cancers12092622
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发表时间：
2020-09-14
期刊：
影响因子：
5.2
通讯作者：
Ban HS
中科院分区：
文献类型：
--
作者：
Han TS;Hur K;Cho HS;Ban HS
非编码RNA如microRNA、长链非编码RNA和环状RNA通过表观遗传关联促进肝细胞癌的发生和进展。长的非编码RNA和环状RNA作为竞争性内源性RNA，其含有miRNA的结合位点，因此与miRNA竞争，这导致促进miRNA靶基因的表达，从而导致肝细胞癌的增殖和转移。竞争性内源性RNA有可能成为肝细胞癌的诊断生物标志物和治疗靶点。非编码RNA（non-coding RNA，ncRNA）的三个主要成员，即微小RNA（microRNA，miRNAs）、长链非编码RNA（longnon-coding RNA，lncRNA）和环状RNA（circRNA，circRNA），在肝细胞癌（hepatocellular carcinoma，HCC）的发生发展中起着重要作用。最近，竞争性内源RNA（ceRNA）调控模型将lncRNA/circRNA描述为miRNA的海绵，以间接调控miRNA下游靶基因。越来越多的证据表明，ceRNA调控网络与HCC中的生物学过程相关，包括癌细胞生长、上皮向间质转化（EMT）、转移和化疗耐药性。本文就近年来发现的肝癌中特异性ceRNA调控网络（lncRNA/circRNA-miRNA-mRNA）及其临床意义作一综述。
Non-coding RNAs such as microRNAs, long non-coding RNAs, and circular RNAs contribute to the development and progression of hepatocellular carcinoma through epigenetic association. Long non-coding RNAs and circular RNAs act as competing endogenous RNAs that contain binding sites for miRNAs and thus compete with the miRNAs, which results in promotion of miRNA target gene expression, thereby leading to proliferation and metastasis of hepatocellular carcinoma. Competing endogenous RNAs have the potential to become diagnostic biomarkers and therapeutic targets for treatment of hepatocellular carcinoma. The three major members of non-coding RNAs (ncRNAs), named microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), play an important role in hepatocellular carcinoma (HCC) development. Recently, the competing endogenous RNA (ceRNA) regulation model described lncRNA/circRNA as a sponge for miRNAs to indirectly regulate miRNA downstream target genes. Accumulating evidence has indicated that ceRNA regulatory networks are associated with biological processes in HCC, including cancer cell growth, epithelial to mesenchymal transition (EMT), metastasis, and chemoresistance. In this review, we summarize recent discoveries, which are specific ceRNA regulatory networks (lncRNA/circRNA-miRNA-mRNA) in HCC and discuss their clinical significance.
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发表时间：
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期刊：
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影响因子：
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