EFFECTS OF CAROTENOIDS IN CELLULAR AND ANIMAL SYSTEMS
EFFECTS OF CAROTENOIDS IN CELLULAR AND ANIMAL SYSTEMS
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DOI：
10.1093/ajcn/53.1.238s
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发表时间：
1991-01-01
影响因子：
7.1
通讯作者：
KRINSKY, NI
中科院分区：
文献类型：
--
作者：
KRINSKY, NI
有人认为类胡萝卜素色素可以作为化学预防剂来降低人类患癌症的风险。 该建议部分取决于流行病学证据，部分取决于在细胞和动物系统中所做的工作。 本文综述了类胡萝卜素抑制致突变性、恶性转化、肿瘤形成和免疫增强的实验证据。 尽管尚未确定这些作用的机制，但很明显，这些系统中压倒性的证据表明类胡萝卜素在调节致癌物的作用方面发挥着重要影响。
It has been suggested that carotenoid pigments may function as chemopreventive agents for reducing the risk of cancer in humans. Part of this suggestion rests on epidemiological evidence, and part rests on work done in cellular and animal systems. In this article, the experimental evidence for carotenoid inhibition of mutagenicity, malignant transformation, tumor formation, and immunoenhancement is reviewed. Although a mechanism for these effects cannot yet be identified, it is clear that the overwhelming evidence in these systems would indicate that carotenoids exert an important influence in modulating the actions of carcinogens.