Clinical myocardial perfusion PET/CT
Clinical myocardial perfusion PET/CT
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DOI：
10.2967/jnumed.106.032789
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发表时间：
2007-05-01
影响因子：
9.3
通讯作者：
Moore, Stephen C.
中科院分区：
文献类型：
--
作者：
Di Carli, Marcelo F.;Dorbala, Sharmila;Moore, Stephen C.
核心脏病学领域对使用心脏 PET 评估冠状动脉疾病 (CAD) 患者的兴趣日益浓厚。现有证据表明，心肌灌注 PET 为诊断阻塞性 CAD 提供了一种准确的方法，它似乎优于 SPECT，尤其是在肥胖者和承受药物应激的患者中。能够记录左心室功能从休息到峰值应力的变化并量化心肌灌注（以 mL/min/g 组织为单位），在评估多血管 CAD 方面比 SPECT 具有额外的优势。越来越多的一致证据表明，门控心肌灌注 PET 还可提供临床上有用的风险分层。尽管混合 PET/CT 技术的引入为在同一环境下评估解剖 CAD（CT 冠状动脉造影）的范围及其功能后果（缺血负荷）提供了令人兴奋的可能性，但在实施基于 CT 的透射成像进行衰减校正方面仍存在技术挑战。尽管如此，这个用于评估解剖学和生物学的综合平台为将分子靶向成像的进步转化为人类提供了巨大的潜力。
The field of nuclear cardiology is witnessing growing interest in the use of cardiac PET for the evaluation of patients with coronary artery disease (CAD). The available evidence suggests that myocardial perfusion PET provides an accurate means for diagnosing obstructive CAD, which appears superior to SPECT especially in the obese and in those undergoing pharmacologic stress. The ability to record changes in left ventricular function from rest to peak stress and to quantify myocardial perfusion (in mL/min/g of tissue) provides an added advantage over SPECT for evaluating multivessel CAD. There is growing and consistent evidence that gated myocardial perfusion PET also provides clinically useful risk stratification. Although the introduction of hybrid PET/CT technology offers the exciting possibility of assessing the extent of anatomic CAD (CT coronary angiography) and its functional consequences (ischemic burden) in the same setting, there are technical challenges in the implementation of CT-based transmission imaging for attenuation correction. Nonetheless, this integrated platform for assessing anatomy and biology offers a great potential for translating advances in molecularly targeted imaging into humans.