Initiation of mammalian liver development from endoderm by fibroblast growth factors
Initiation of mammalian liver development from endoderm by fibroblast growth factors
复制标题
DOI：
10.1126/science.284.5422.1998
复制
发表时间：
1999-06-18
期刊：
影响因子：
56.9
通讯作者：
Zaret, KS
中科院分区：
文献类型：
--
作者：
Jung, JN;Zheng, MH;Zaret, KS
从哺乳动物肠道内胚层诱导肝脏的胚胎诱导或诱导其他肠道来源器官的信号分子尚不清楚。靠近表达成纤维细胞生长因子（FGFs） 1、2和8的心脏中胚层，导致前肠内胚层发育成肝脏。用FGF1或FGF2（而不是FGF8）处理小鼠胚胎分离的前肠内胚层，足以取代心脏中胚层作为肝脏基因表达程序的诱导剂，后者是肝发生的第一步。肝原性的;反应仅限于内胚层组织，其选择性地共表达FGF受体1和4。对FGFs及其特异性抑制剂的进一步研究表明，FGF8有助于肝内胚层的形态发生生长。因此，在哺乳动物器官发生过程中，不同的FGF信号似乎启动了不同的肝脏发育阶段。
The signaling molecules that elicit embryonic induction of the liver from the mammalian gut endoderm or induction of other gut-derived organs are unknown. Close proximity of cardiac mesoderm, which expresses fibroblast growth factors (FGFs) 1, 2, and 8, causes the foregut endoderm to develop into the liver. Treatment of isolated foregut endoderm from mouse embryos with FGF1 or FGF2, but not FGF8, was sufficient to replace cardiac mesoderm as an inducer of the Liver gene expression program, the latter being the first step of hepatogenesis. The hepatogenic; response was restricted to endoderm tissue, which selectively coexpresses FGF receptors 1 and 4. Further studies with FGFs and their specific inhibitors showed that FGF8 contributes to the morphogenetic outgrowth of the hepatic endoderm. Thus, different FGF signals appear to initiate distinct phases of liver development during mammalian organogenesis.