Cells
Cells
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DOI：
10.1007/978-3-030-24517-7_3
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Bettina Mannerström;S. Kaur;Riitta Seppänen-Kaijansinkko
中科院分区：
文献类型：
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作者：
Bettina Mannerström;S. Kaur;Riitta Seppänen-Kaijansinkko
再生医学利用被称为TE三角的细胞、生物材料和分子来再生因疾病或伤害而受损的身体结构。细胞是这个三位一体的重要组成部分。干细胞有几种不同的来源，具有不同的效力。成体干细胞可分化为来源于单一胚层的组织，如间充质干细胞(MSCs)，可形成脂肪组织、骨和软骨。最近的研究表明，在MSCs观察到的治疗潜力背后的驱动力是细胞分泌的旁分泌因子。这些因子刺激细胞的增殖和分化，其机制与组织发育或愈合过程中的机制相同。了解干细胞体外繁殖过程中受旁分泌因子控制和调节的分子事件，将为更有效地将这些细胞用于治疗目的提供替代方法。
Regenerative medicine makes use of cells, biomaterials, and molecules, known as the TE triangle, to regenerate damaged structures in the body due to disease or injury. The cells are an important component of this triad. There are several sources of stem cells with varying potencies. Adult stem cells may differentiate into tissues derived from a single germ layer such as mesenchymal stem cells (MSCs), which may form adipose tissue, bone, and cartilage. Recent studies suggest that the driving force behind the therapeutic potential observed in MSCs is the paracrine factors secreted by the cells. These factors stimulate cell proliferation and differentiation following the same mechanism that occurs during tissue development or healing. The understanding of the molecular events that are controlled and regulated by the paracrine factors during in vitro propagation of the stem cells would render alternative approaches in applying these cells for therapeutic purposes more effectively.