Do genetic factors contribute to the association between birth weight and blood pressure?
Do genetic factors contribute to the association between birth weight and blood pressure?
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DOI：
10.1136/jech.55.8.583
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发表时间：
2001-08-01
影响因子：
6.3
通讯作者：
McGue, M
中科院分区：
文献类型：
--
作者：
Christensen, K;Stovring, H;McGue, M
目的：评估遗传因素是否与青春期低出生体重和血压升高之间存在关联。设计-双胞胎历史队列研究。评估是否(1)在整个双胞胎样本中发现出生体重和收缩压之间的负相关，以及(2)出生体重的内部差异是否与收缩压的内部差异相关，从而控制遗传因素的影响(全部为单卵，平均一半为异卵双生)。背景-明尼苏达双胞胎家庭研究。参与者-1311对青少年双胞胎。主要结果-在整个样本中，出生体重和收缩血压之间存在负相关。控制当前体重后的回归系数为-1.88毫米汞/公斤(SE 0.61)，与先前对独生子女青少年的研究结果一致。经对内分析后，回归系数降至-0.64 mm Hg/kg(SE 0.86)。在同卵双胞胎中观察到的降幅最大：从整个同卵双胞胎样本中的-2.44 mm Hg/kg(SE 0.75)下降到单卵对内差异分析中的-1.06 mm Hg/kg(SE 1.14)。结论-低出生体重与晚年血压升高之间的关联是成立的。“胎儿程序化假说”表明，这种联系是由宫内营养不良引起的，而一种新的假说“胎儿胰岛素假说”则认为，遗传决定的胰岛素抵抗也对这种联系起到了重要作用。最近一项关于中年双胞胎的双胞胎研究没有证据表明遗传因素的影响，而这项规模更大的研究为胎儿胰岛素假说提供了支持：当遗传因素被控制时，青少年出生体重和血压之间的关联减弱。综上所述，这表明遗传因素对胎儿生长和青春期收缩压之间的关联有重要贡献。
Objectives-To evaluate whether genetic factors contribute to the association between low birth weight and increased blood pressure among adolescents.Design-Historical cohort study of twin pairs. It was evaluated whether (1) a negative association between birth weight and systolic blood pressure was found in the overall twin sample and (2) whether the intrapair difference in birth weight correlated with the intrapair difference in systolic blood pressure-thereby controlling for the effect of genetic factors (all in monozygotic and on average half in dizygotic pairs).Setting-The Minnesota Twin Family Study.Participants-1311 pairs of adolescent twins.Main results-A negative association between birth weight and systolic blood pressure was retrieved in the overall sample. The regression coefficient after controlling for current weight was -1.88 mm Hg/kg (SE 0.61), which corresponds to results from previous studies of singleton adolescents. The regression coefficient fell to -0.64 mm Hg/kg (SE 0.86) when the intrapair analyses were used. The largest reduction was observed among monozygotic twins: from -2.44 mm Hg/kg (SE 0.75) in the overall monozygotic twin sample to -1.06 mm Hg/kg (SE 1.14) in the analyses of the within monozygotic pair differences.Conclusion-The association between low birth weight and increased blood pressure later in life is well established. "The fetal programming hypothesis" suggests that the association is caused by intrauterine malnutrition while a new hypothesis "the fetal insulin hypothesis" proposes that genetically determined insulin resistance also contributes significantly to the association. A recent twin study of middle aged twins showed no evidence for an influence of genetic factors while this larger study provides support for the fetal insulin hypothesis: the association between birth weight and blood pressure attenuated among adolescents when genetic factors were controlled. Together this suggests an important contribution of genetic factors to the association between fetal growth and systolic blood pressure in adolescence.