Pharmacological agents acting at subtypes of metabotropic glutamate receptors
Pharmacological agents acting at subtypes of metabotropic glutamate receptors
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DOI：
10.1016/s0028-3908(99)00092-1
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发表时间：
1999-10-01
影响因子：
4.7
通讯作者：
Monn, JA
中科院分区：
文献类型：
--
作者：
Schoepp, DD;Jane, DE;Monn, JA
代谢型（G蛋白偶联）谷氨酸（mGlu）受体现已成为公认的，但仍然是相对较新的兴奋性氨基酸研究领域。最近，各种结构新颖的、有效的和mGlu受体选择性药理学试剂的出现推动了对mGlu受体亚型在中枢神经系统的生理/病理生理功能中的作用和参与的当前理解。本文回顾了已报道的靶向mGlu受体的药理学药物的演变，重点关注当前药物已知的受体亚型选择性。(C)1999爱思唯尔科技有限公司。保留所有权利。
Metabotropic (G-protein-coupled) glutamate (mGlu) receptors have now emerged as a recognized, but still relatively new area of excitatory amino acid research. Current understanding of the roles and involvement of mGlu receptor subtypes in physiological/pathophysiological functions of the central nervous system has been recently propelled by the emergence of various structurally novel, potent, and mGlu receptor selective pharmacological agents. This article reviews the evolution of pharmacological agents that have been reported to target mGlu receptors, with a focus on the known receptor subtype selectivities of current agents. (C) 1999 Elsevier Science Ltd. All rights reserved.