B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma
B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma
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DOI：
10.1016/j.bbrc.2007.10.156
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发表时间：
2008-01-04
影响因子：
3.1
通讯作者：
Inoue, Hiromasa
中科院分区：
文献类型：
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作者：
Matsumoto, Koichiro;Fukuyama, Satoru;Inoue, Hiromasa
B7- dc是一种共刺激分子，属于B7家族。我们之前发现，在效应期使用抗b7 - dc单抗治疗可增强小鼠的哮喘表型。我们研究了B7-DC诱导的机制以及B7-DC如何调节哮喘表型。在过敏原挑战的ifn - γ缺乏小鼠中，抗B7-DC单抗未能增强哮喘表型，尽管B7-DC对小鼠树突状细胞的诱导作用与野生型小鼠的树突状细胞相当。IL-13可上调树突状细胞的B7-DC。在体内，阻断IL-13可减弱B7-DC对树突状细胞的诱导作用。b7 - dc缺陷小鼠的哮喘表型比野生型小鼠增强。这种增强与ifn - γ的下调和IL-13的上调同时发生。这些结果表明，IL-13诱导的B7-DC在过敏性哮喘的效应期通过上调ifn - γ的产生而发挥反馈调节作用。(c) 2007爱思唯尔公司版权所有。
B7-DC is a costimulatory molecule belonging to the B7 family. We previously found that treatment with anti-B7-DC mAb during the effector phase enhances asthma phenotypes in mice. We investigated the mechanisms of B7-DC induction and how B7-DC regulates asthma phenotypes. In allergen-challenged IFN-gamma-deficient mice, anti-B7-DC mAb failed to enhance the asthma phenotypes although the induction of B7-DC on dendritic cells of the mice was comparable with that on dendritic cells of wild-type mice. B7-DC on dendritic cells was up-regulated by IL-13 in vitro. The induction of B7-DC on dendritic cells after allergen challenge was attenuated by blockade of IL-13 in vivo. The asthma phenotypes were enhanced in B7-DC-deficient mice, more than in wild-type mice. The enhancement was concurrent with the down-regulation of IFN-gamma and up-regulation of IL-13. These results suggest that B7-DC induced by IL-13 works as a feedback regulator by up-regulating IFN-gamma production during the effector phase of allergic asthma. (c) 2007 Elsevier Inc. All rights reserved.