Common Elements Treatment Approach (CETA) for unhealthy alcohol use among persons with HIV in Zambia: Study protocol of the ZCAP randomized controlled trial.
Common Elements Treatment Approach (CETA) for unhealthy alcohol use among persons with HIV in Zambia: Study protocol of the ZCAP randomized controlled trial.
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DOI：
10.1016/j.abrep.2020.100278
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发表时间：
2020-12-01
影响因子：
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通讯作者：
Vinikoor, Michael J
中科院分区：
文献类型：
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作者：
Kane, Jeremy C;Sharma, Anjali;Vinikoor, Michael J
目标：在撒哈拉以南非洲（SSA），不健康的酒精使用和同时发生的心理健康问题在艾滋病毒感染者（PLWH）中的流行率很高。然而，缺乏循证治疗方案，可以解决不健康的酒精使用和合并症在SSA艾滋病毒护理设置。最近在SSA的PLWH中测试单次酒精短暂干预（BI）的研究表明，需要更强大的治疗。本文描述了一项试点随机对照优效性试验的方案，该试验将测试循证跨诊断多疗程心理治疗的有效性，共同要素治疗方法（CETA），与基于CETA的单次短暂酒精干预（BI）组成的对照条件相比，在减少不健康的酒精使用，心理健康问题，方法：本研究是在卢萨卡的HIV治疗中心进行的单盲、平行、个体随机试验。160名符合不健康饮酒+心理健康或药物使用合并症标准和/或患有更严重的饮酒障碍的PLWH有资格。受试者以1：1的比例随机接受单次BI或CETA。在基线和6个月的随访结果进行评估，包括不健康的酒精使用，抑郁症，创伤症状，和其他substance use.CONCLUSIONS：该试验是第一步，在建立CETA的有效性，减少不健康的酒精使用和合并症之间PLWH在SSA。如果有效性得到证实，将进行一项更大规模的试验，以长期随访和艾滋病毒治疗结果为特征。
AIMS: Prevalence of unhealthy alcohol use and co-occurring mental health problems is high among persons living with HIV (PLWH) in sub-Saharan Africa (SSA). Yet, there is a dearth of evidence-based treatment options that can address both unhealthy alcohol use and comorbidities in SSA HIV care settings. Recent studies testing single-session alcohol brief interventions (BIs) among PLWH in SSA have suggested that more robust treatments are needed. This paper describes the protocol of a pilot randomized controlled superiority trial that will test the effectiveness of an evidence-based transdiagnostic multi-session psychotherapy, the Common Elements Treatment Approach (CETA), compared to a control condition consisting of a single session brief alcohol intervention (BI) based on CETA, at reducing unhealthy alcohol use, mental health problems, and other substance use among PLWH in urban Zambia.METHODS: The study is a single-blind, parallel, individually randomized trial conducted in HIV treatment centers in Lusaka. 160 PLWH who meet criteria for unhealthy alcohol use+mental health or substance use comorbidities and/or have a more severe alcohol use disorder are eligible. Participants are randomized 1:1 to receive the single-session BI or CETA. Outcomes are assessed at baseline and a six-month follow-up and include unhealthy alcohol use, depression, trauma symptoms, and other substance use.CONCLUSIONS: The trial is a first step in establishing the effectiveness of CETA at reducing unhealthy alcohol use and comorbidities among PLWH in SSA. If effectiveness is demonstrated, a larger trial featuring long-term follow-ups and HIV treatment outcomes will be undertaken.