A negative regulatory element with properties similar to those of enhancers is contained within an Alu sequence
A negative regulatory element with properties similar to those of enhancers is contained within an Alu sequence
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Alu 序列中包含具有与增强子类似特性的负调控元件
DOI：
10.1128/mcb.9.2.355-364.1989
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发表时间：
1989
影响因子：
5.3
通讯作者：
S. J. Thurston
中科院分区：
文献类型：
--
作者：
J. D. Saffer;S. J. Thurston
在非洲绿猴Alu家族散布重复序列的成员中发现了一个负调控元件。这种“还原”元件减少了细胞内类似猴病毒40的双向启动子的双向转录，而不受方向和位置的影响。该还原剂不是启动子特异性的，因为它也降低了猴病毒40早期和人β-珠蛋白启动子的表达。此外，该还原剂还减少了聚合酶III启动子的转录。该还原子包含在Alu家族成员的38个碱基对中，并与猴子细胞核蛋白特异地相互作用。
A negative regulatory element has been found within a member of the African green monkey Alu family of interspersed repeated sequences. This "reducer" element decreased transcription in both directions from a cellular simian virus 40-like bidirectional promoter independently of both orientation and position. The reducer was not promoter specific since it also decreased expression from the simian virus 40 early and human beta-globin promoters. In addition, the reducer decreased transcription from a polymerase III promoter. The reducer was contained in 38 base pairs of an Alu family member and interacted specifically with a monkey cell nuclear protein.