Obesity among HIV-infected persons: impact of weight on CD4 cell count
Obesity among HIV-infected persons: impact of weight on CD4 cell count
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DOI：
10.1097/qad.0b013e328337fe01
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发表时间：
2010-04-24
期刊：
影响因子：
3.8
通讯作者：
Agan, Brian K.
中科院分区：
文献类型：
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作者：
Crum-Cianflone, Nancy F.;Roediger, Mollie;Agan, Brian K.
为了评估肥胖对 CD4 细胞计数的影响，我们估计了 1001 名记录在案的 HIV 血清转化者中随时间更新的 BMI 类别与 CD4 变化之间的关联。在前高活性抗逆转录病毒治疗 (HAART) 时代，随着时间的推移，较高的 BMI 与 CD4 细胞计数减少较少相关。然而，在HAART时代，肥胖患者与正常体重患者相比，CD4细胞计数增加较小（+69个细胞与+116个细胞，P=0.01）。 CD4 细胞计数降低现在可能是肥胖的另一个不利后果。
To assess the effect of obesity on CD4 cell counts, we estimated the association of time-updated BMI categories with CD4 changes among 1001 documented HIV seroconverters. During the pre-highly active antiretroviral therapy (HAART) era, a higher BMI was associated with less reduction in CD4 cell counts over time. However during the HAART era, obese versus normal weight patients had smaller increases in CD4 cell counts (+69 versus +116 cells, P=0.01). Lower CD4 cell counts may now be another adverse consequence of obesity.