Myocutaneous flaps in patients with head and neck cancer retain their immunological capacities in an activated functional state
Myocutaneous flaps in patients with head and neck cancer retain their immunological capacities in an activated functional state
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DOI：
10.1111/j.1600-0714.1997.tb00006.x
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发表时间：
1997-01-01
影响因子：
3.3
通讯作者：
Millesi, W
中科院分区：
文献类型：
--
作者：
Kornfehl, J;Formanek, M;Millesi, W
应用免疫组织化学（APAAP）技术对口腔/口咽部晚期鳞状细胞癌根治术后游离/带蒂肌皮瓣进行了检测。在手术时以及术后3个月和5个月，对8名患者进行了活检。15个单克隆抗体被用来检测表面抗原作为免疫活性细胞表型变化的标志。在术后活检中，所有研究的抗原均显著增加。CD 45 RO+细胞数量显著高于对照组（P
Free/pedicled myocutaneous flaps used as functional replacement after radical dissection of advanced stage squamous cell carcinomas of the oral cavity/oropharynx were examined by immunohistochemistry (APAAP-technique). Biopsies from eight patients were taken at the time of surgery and at 3 and 5 months postoperatively. Fifteen monoclonal antibodies were used to detect surface antigens as markers of phenotypic changes of immune competent cells. In post-operative biopsies all antigens investigated increased significantly. Significantly higher numbers of CD45RO+ (P