The impact of subchondral bone cysts on local bone stresses in the medial femoral condyle of the equine stifle joint
The impact of subchondral bone cysts on local bone stresses in the medial femoral condyle of the equine stifle joint
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DOI：
10.1016/j.medengphy.2017.06.019
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发表时间：
2017-10-01
影响因子：
2.2
通讯作者：
Fischer, Kenneth J.
中科院分区：
文献类型：
--
作者：
Frazer, Lance L.;Santschi, Elizabeth M.;Fischer, Kenneth J.
软骨下透明(SCL)，也被称为软骨下骨囊肿，可导致马和人类的临床问题。在人类中，由于机械因素(通常与运动有关)和继发于骨关节炎(OA)的骨骼成熟个体，SCLS发生在青年和青少年[1]。在马中，SCL最常发生在生长期马(无骨性关节炎)的股骨内侧髁(MFC)，并导致跛行。马SCL的原因尚有争议，但超负荷造成的骨损伤可能是其机制。研究健康囊性MFC的生物力学对于了解囊性MFC的生长和为新的治疗策略提供基础是非常重要的。我们假设SCL改变了周围骨骼的力学环境，在持续加载的情况下，这可能导致SCL的增大。在这项研究中，我们开发并验证了马窒息关节的有限元模型，并研究了与不同尺寸的SCL相关的应力。我们发现，在SCL发育的不同阶段，拉伸应力和剪应力存在显著差异，这表明进一步的骨损伤会导致SCL增大。这些数据为了解SCL周围软骨下骨改变的力学机制提供了第一步。更多的研究可能为改进幼马SCL的治疗策略提供基础，并可能提高对人类SCL的理解。(C)2017年IPEM。爱思唯尔有限公司出版。保留所有权利。
Subchondral lucency (SCL), also referred to as subchondral bone cysts, can cause clinical problems in horses and humans. In humans, SCLs occur in youths and adolescents [1] due to mechanical factors (often related to athletics) and in skeletally mature individuals secondary to osteoarthritis (OA). In horses, SCL most commonly occurs in the medial femoral condyle (MFC) of growing horses (without OA), and causes lameness. The cause of equine SCL is debated, but bone trauma due to overload is the likely mechanism. Investigating the biomechanics of the healthy and cystic MFC is important to understand cyst growth and to provide a foundation for new treatment strategies. We hypothesize that SCL alters the mechanical environment of surrounding bone, which in the presence of continued loading, may lead to enlargement of the SCL. In this study, we developed and validated a finite element model of an equine stifle joint and investigated the stresses associated with varying sizes of SCL. We found substantial differences in tensile and shear stress at various stages of SCL development that suggest further bone damage leading to SCL enlargement. These data provide a first step in understanding of the altered mechanics of subchondral bone surrounding a SCL. Additional studies may provide the basis for improved treatment strategies for SCL in young horses, and may improve the understanding of SCL in humans. (C) 2017 IPEM. Published by Elsevier Ltd. All rights reserved.