The influence of stress and gonadal hormones on neuronal structure and function.
The influence of stress and gonadal hormones on neuronal structure and function.
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DOI：
10.1016/j.yhbeh.2015.03.003
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发表时间：
2015-11
影响因子：
3.5
通讯作者：
Shansky RM
中科院分区：
文献类型：
--
作者：
Farrell MR;Gruene TM;Shansky RM
大脑具有高度的可塑性，使我们能够适应和应对环境和生理挑战和经验。在这篇综述中，我们讨论了由于压力暴露，内源性激素波动，或外源性激素操纵的树突状分支，棘形态和行为的改变之间的关系。很少有研究直接在同一组动物中调查结构-功能关联，并且在前额叶皮层和海马的结构-功能关系证据中存在明显的不一致。此外，几乎没有工作已经做了探索树突形态和神经元兴奋性之间的因果关系，只留下猜测的经验依赖性树突重塑的适应性与适应不良的性质。我们建议，未来的研究结合联合收割机电生理学与电路水平的方法，以更好地了解树突结构如何有助于神经元的功能特性和行为结果。
The brain is highly plastic, allowing us to adapt and respond to environmental and physiological challenges and experiences. In this review, we discuss the relationships among alterations in dendritic arborization, spine morphology, and behavior due to stress exposure, endogenous hormone fluctuation, or exogenous hormonal manipulation. Very few studies investigate structure-function associations directly in the same cohort of animals, and there are notable inconsistencies in evidence of structure-function relationships in the prefrontal cortex and hippocampus. Moreover, little work has been done to probe the causal relationship between dendritic morphology and neuronal excitability, leaving only speculation about the adaptive versus maladaptive nature of experience-dependent dendritic remodeling. We propose that future studies combine electrophysiology with a circuit-level approach to better understand how dendritic structure contributes to neuronal functional properties and behavioral outcomes.