Antibodies to Toxoplasma gondii in patients with schizophrenia:: A meta-analysis
Antibodies to Toxoplasma gondii in patients with schizophrenia:: A meta-analysis
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DOI：
10.1093/schbul/sbl050
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发表时间：
2007-05-01
影响因子：
6.6
通讯作者：
Yolken, Robert H.
中科院分区：
文献类型：
--
作者：
Torrey, E. Fuller;Bartko, John J.;Yolken, Robert H.
最近的研究将传染性病原体与精神分裂症联系起来。数量最多的研究涉及对刚地弓形虫的分析；这些研究进行了荟萃分析。通过MEDLINE、Ovid和谷歌Scholar检索已发表的文章和摘要；检索中文出版物；通过给研究人员的信；以及访问中国。使用血清学方法测量弓形虫抗体来评估诊断为精神分裂症的住院和/或门诊患者的已发表和未发表的对照研究被选中进行分析，并根据需要翻译源文件。确定了50年来在17个国家进行的42项研究；其中23篇（6篇未发表）符合选择标准。合并优势比（OR）为2.73（95%置信区间2.10 ~ 3.60）
Recent studies have linked infectious agents to schizophrenia. The largest number of studies has involved the analysis of Toxoplasma gondii; these studies were subjected to a meta-analysis. Published articles and abstracts were identified by searches of MEDLINE, Ovid, and Google Scholar; by a search of Chinese publications; through letters to researchers; and by visiting China. Published and unpublished controlled studies that used serological methods for measuring T. gondii antibodies to assess inpatients and/or outpatients diagnosed with schizophrenia were selected for analysis, and source documents were translated as needed. Forty-two studies carried out in 17 countries over 5 decades were identified; 23 of these (6 unpublished) met selection criteria. The combined odds ratio (OR) was 2.73 (95% confidence interval, 2.10 to 3.60; chi-square with I df 263; P