The Warburg effect: molecular aspects and therapeutic possibilities
The Warburg effect: molecular aspects and therapeutic possibilities
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DOI：
10.1007/s11033-014-3764-7
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发表时间：
2015-04-01
影响因子：
2.8
通讯作者：
Karagiannis, Tom C.
中科院分区：
文献类型：
--
作者：
Hanh Ngo;Tortorella, Stephanie M.;Karagiannis, Tom C.
自从奥托·瓦尔堡提出关于癌细胞代谢的建议以来，已经过去了大约90年。与在氧存在下经历糖酵解和氧化磷酸化的正常细胞不同，增殖细胞和癌细胞表现出增加的葡萄糖摄取和增加的糖酵解速率，并且主要经历乳酸发酵。这种现象是癌症遗传失调的结果还是癌症的原因仍然未知。然而，遗传因素、表观遗传调节、癌症免疫监视和瓦尔堡效应之间肯定有很强的联系，这将在本文中讨论。二氯乙酸和3-溴丙酮酸是已被研究作为潜在癌症疗法的物质之一。随着我们对细胞代谢知识的不断扩展，靶向瓦尔堡效应的治疗似乎非常有希望。本文综述了这些新兴疗法的不同方面。
It has been about nine decades since the proposal of Otto Warburg on the metabolism of cancer cells. Unlike normal cells which undergo glycolysis and oxidative phosphorylation in the presence of oxygen, proliferating and cancer cells exhibit an increased uptake of glucose and increased rate of glycolysis and predominantly undergo lactic acid fermentation. Whether this phenomenon is the consequence of genetic dysregulation in cancer or is the cause of cancer still remains unknown. However, there is certainly a strong link between the genetic factors, epigenetic modulation, cancer immunosurveillance and the Warburg effect, which will be discussed in this review. Dichloroacetate and 3-bromopyruvate are among the substances that have been studied as potential cancer therapies. With our expanding knowledge of cellular metabolism, therapies targeting the Warburg effect appear very promising. This review discusses different aspects of these emerging therapies.