Effects of Ramadan Fasting on Serum Amyloid A and Protein Carbonyl Group Levels in Patients With Cardiovascular Diseases.
Effects of Ramadan Fasting on Serum Amyloid A and Protein Carbonyl Group Levels in Patients With Cardiovascular Diseases.
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DOI：
10.15171/jcvtr.2015.12
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发表时间：
2015
影响因子：
1.1
通讯作者：
Yousefi B
中科院分区：
文献类型：
--
作者：
Asadi H;Abolfathi AA;Badalzadeh R;Majidinia M;Yaghoubi A;Asadi M;Yousefi B
简介：血清淀粉样蛋白A（SAA）和蛋白质羰基分别作为急性炎症状态的敏感标志物和氧化应激的重要指标与心血管疾病（CVD）密切相关。此外，饮食是可以改变心血管风险的主要因素之一。因此，本研究旨在研究斋月禁食对心血管疾病患者SAA和蛋白质羰基水平的影响。 研究方法：21例患有CVD（冠状动脉疾病、脑血管疾病或外周动脉疾病）的患者（21例男性;平均年龄52±9岁）参加了本研究。在斋月禁食前2天和禁食后2天测量患者的生化参数。SAA水平进行了评估，使用酶联免疫吸附测定和开曼蛋白羰基比色测定提供测量蛋白质羰基。 结果如下：根据研究结果，与空腹前的基线值相比，CVD患者的炎症生物标志物SAA的斋月后水平显著降低（16.84±8.20 vs. 24.40±6.72 μg/ml，P = 0.021）。此外，斋月禁食使患者血浆蛋白羰基水平显著降低（33.08±15.31 vs.43.65 ±16.88 nmol/ml，P = 0.039）。 结论：斋月禁食通过降低炎症和氧化应激标志物对调节心血管疾病具有显著作用。然而，为了得到一个明确的结论，更多的结果，进一步的调查是必要的。
Introduction: Serum amyloid-A (SAA) and protein carbonyl group are rigorously related with cardiovascular diseases (CVDs) as a sensitive marker of an acute inflammatory state and as an important index of oxidative stress, respectively. Moreover, diet is one of the main factors that can modify cardiovascular risks. Therefore, this study aimed to investigate the effects of Ramadan fasting on SAA and protein carbonyl group levels in patients with CVDs. Methods: Twenty-one patients (21 male; mean age 52±9 years old) with CVDs (coronary artery disease, cerebrovascular, or peripheral arterial diseases) were participated in this study. Biochemical parameters were measured in patients 2 days before and 2 days after Ramadan fasting. SAA levels were assessed using enzyme-linked immunosorbent assay and Cayman’s protein carbonyl colorimetric assay was provided for measuring protein carbonyl groups. Results: According to the findings of the study, post-Ramadan levels of inflammatory biomarker, SAA was decreased significantly in patients with CVDs in comparison with the baseline before-fasting values (16.84±8.20 vs. 24.40±6.72 μg/ml, P = 0.021). In addition, Ramadan fasting significantly reduced the levels of protein carbonyl group in patients as compared with those of baseline values (33.08±15.31 vs. 43.65±16.88 nmol/ml, P = 0.039). Conclusion: Ramadan fasting has impressive effects on modulating CVDs by decreasing inflammation and oxidative stress markers. However, to get a clear conclusion with more results, further investigation is warranted.