Cancer stem cells: An insight.
Cancer stem cells: An insight.
复制标题
DOI：
10.4103/jomfp.jomfp_132_16
复制
发表时间：
2017-09
期刊：
影响因子：
--
通讯作者：
Bodhade A
中科院分区：
文献类型：
--
作者：
Moharil RB;Dive A;Khandekar S;Bodhade A
肿瘤干细胞具有自我更新的能力，存在于大多数组织中，包括乳腺、脑、肺、头颈部、前列腺、睾丸、卵巢、食道、结肠和肝脏。尽管在这方面提出了一系列假说，但它们的起源尚未被发现。肿瘤干细胞不仅在肿瘤的发生、发展、转移和复发中起着重要作用。肿瘤干细胞在肿瘤治疗和化疗药物耐药中发挥着重要作用。本文就肿瘤干细胞的来源、分离方法和肿瘤治疗等方面的特点进行综述。
Cancer stem cells (CSCs) have the ability to self-renew and are present in most tissues including breast, brain, lung, head and neck, prostates, testis, ovary, esophagus, colon and liver. Their origin is yet to be discovered though a series of hypotheses have been proposed in this regard. CSCs play a role in not only the creation of cancer but also its evolution, metastasis and recurrence. CSCs have an important role in cancer therapy and the resistance toward chemotherapeutic agents. This article reviews the characteristics of CSCs in terms of origin, methods of isolation and cancer therapy.