Gender effects on age-related changes in brain structure.
Gender effects on age-related changes in brain structure.
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发表时间：
2000
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通讯作者：
Jiang Xu;S. Kobayashi;S. Yamaguchi;K. Iijima;K. Okada;K. Yamashita
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作者：
Jiang Xu;S. Kobayashi;S. Yamaguchi;K. Iijima;K. Okada;K. Yamashita
背景和目的以往的研究表明，脑萎缩与衰老有关，并且随着年龄的增长，脑萎缩存在性别差异。然而，这些报告既没有排除"健康受试者"的无症状脑损伤，也没有将大脑划分为亚区域。本研究的目的是通过磁共振成像来阐明性别对大脑亚区域年龄相关变化的影响。方法应用计算机辅助系统对331例无脑病变的受试者的MRI图像进行脑物质面积指数（BMAI）计算。结果随着年龄的增长，男性右额叶后部脑萎缩明显多于女性。在男性受试者中也发现了右侧颞叶中部、左侧基底神经节、顶叶和小脑的脑萎缩，但在女性受试者中没有发现。在颞叶、丘脑、顶枕叶和小脑中，左半球的脑体积显著小于右半球;性别和年龄不影响这些区域脑体积的半球差异。结论性别对增龄性脑萎缩的影响在不同脑区存在差异。随着年龄的增长，男性脑萎缩的发生率高于女性。
BACKGROUND AND PURPOSE Previous reports have suggested that brain atrophy is associated with aging and that there are gender differences in brain atrophy with aging. These reports, however, neither exclude silent brain lesions in "healthy subjects" nor divide the brain into subregions. The aim of this study is to clarify the effect of gender on age-related changes in brain subregions by MR imaging. METHODS A computer-assisted system was used to calculate the brain matter area index (BMAI) of various regions of the brain from MR imaging of 331 subjects without brain lesions. RESULTS There was significantly more brain atrophy with aging in the posterior parts of the right frontal lobe in male subjects than there was in female subjects. Age-related atrophy in the middle part of the right temporal lobe, the left basal ganglia, the parietal lobe, and the cerebellum also was found in male subjects, but not in female subjects. In the temporal lobe, thalamus, parieto-occipital lobe, and cerebellum, brain volume in the left hemisphere is significantly smaller than in the right hemisphere; sex and age did not affect the hemisphere differences of brain volume in these regions. CONCLUSION The effect of gender on brain atrophy with aging varied in different subregions of the brain. There was more brain atrophy with aging in male subjects than in female subjects.