Gender and onset age related-differences of non-motor symptoms and quality of life in drug-naive Parkinson's disease
Gender and onset age related-differences of non-motor symptoms and quality of life in drug-naive Parkinson's disease
复制标题
初治帕金森病的非运动症状和生活质量的性别和发病年龄相关差异
DOI：
10.1016/j.clineuro.2018.11.001
复制
发表时间：
2018-12-01
影响因子：
1.9
通讯作者：
Shang, Huifang
中科院分区：
文献类型：
--
作者：
Hu, Tao;Ou, Ruwei;Shang, Huifang
目的：本研究的目的是探讨性别和发病年龄相关的差异，非运动症状（NMS）和生活质量（QoL）的决定因素在一个大队列的中国药物初治帕金森病（PD）patients and methods：一个横断面分析569药物初治PD患者进行。采用非运动症状量表（NMSS）评估各NMS的发生率和严重程度。采用PD问卷-39（PDQ-39）评估PD患者的生活质量。结果：552例患者（97.0%）至少有一种NMS，其中100例患者（12.0%）有一种NMS。最常见的三种NMS是睡眠/疲劳（74%），注意力/记忆（62.7%）和杂项（62%）。女性睡眠/疲劳、情绪/冷漠的发生率高于男性，男性排尿和性功能障碍的发生率高于女性（P < 0.05）。晚发性PD患者的知觉/幻觉、注意/记忆、胃肠道、泌尿系统、性功能障碍及其他方面的发生率高于早发性PD患者（P < 0.05）。多元回归分析模型显示，女性、病程、NMRS III评分、抑郁和NMSS亚核心（睡眠/疲劳、情绪/冷漠、注意/记忆和胃肠道）是药物初治PD患者生活质量的决定因素。它们在药物初治PD患者中是异质性的，这是PD患者生活质量下降的显著决定因素。我们的研究结果是有益的NMS的药物初治PD的临床管理。
Objective: This study aims to explore the gender and onset age-related differences of non-motor symptoms (NMS) and the determinants of quality of life (QoL) in a large cohort of Chinese drug-naive Parkinson's disease (PD) patients.Patients and methods: A cross-sectional analysis of 569 drug-naive PD patients was conducted. The frequency and severity of each NMS was evaluated by Non-Motor Symptom Scale (NMSS), which consists of 9 subdomains. PD Questionnaire-39 (PDQ-39) was used to assess the QoL of PD patients. A stepwise multiple regression model was used to explore the determinants of QoL.Results: A total of 552 patients (97.0%) exhibited at least one NMS. The three most common NMS were sleep/ fatigue (74%), attention/memory (62.7%) and miscellaneous (62%). The frequencies of sleep/fatigue and mood/apathy were more prevalent in women and the frequencies of urinary and sexual dysfunction were more prevalent in men (P < 0.05). Patients with late-onset PD showed higher frequencies of perceptual problems/ hallucinations, attention/memory, gastrointestinal, urinary, sexual dysfunction, and miscellaneous compared to patients with early-onset PD (P < 0.05). The multiple regression analysis model indicated that female, disease duration, UPDRS III score, depression, and NMSS subcores including sleep/fatigue, mood/apathy, attention/ memory, and gastrointestinal were the determinants of QoL in patients with drug-naive PD.Conclusions: NMS was common in untreated PD patients. They are heterogeneous in patients with drug-naive PD, which are dramatic determinants on decreased QoL in PD. Our results are beneficial for clinical management of NMS in drug-naive PD.