cFUT8 promotes liver cancer progression by miR-548c/FUT8 axis
cFUT8 promotes liver cancer progression by miR-548c/FUT8 axis
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DOI：
10.1038/s41392-020-00393-3
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发表时间：
2021
影响因子：
39.3
通讯作者：
Zhu Hong
中科院分区：
文献类型：
--
作者：
Li Chong;Xin Zhuoyuan;He Luyun;Ning Jing;Lin Kaisu;Pan Jiahui;Rao Jagannatha;Wang Guoqing;Zhu Hong
Dear Editor,Hepatocellular carcinoma (HCC) is a serious and lethal malignancy.According to the global cancer statistics of 2018 (GLOBOCAN 2018) provided by the World Health Organization,HCC led to an estimated 781,631 deaths in 2018,comprising 8.2% of the global cancer mortality burden.Despite improvements in the HCC survival rate,most patients still suffer from metastases and recurrence within 5 years post-surgery.2 And it is the unclear molecular pathogenesis that hampers the control of HCC.The discovery of circular RNAs (circRNAs) has the potential to provide new opportunities but also presents several new challenges.3 Therefore,there is an urgent need to identify the regulatory role of circRNAs in HCC progression.As a novel molecular regulator,circRNAs have been confirmed to control the progression of HCC,typically acting as RNA sponges.Likewise,in this study,we determined that the circRNA cFUT8 can promote HCC development by binding free miR-548c and inhibiting the miR-548c/FUT8 regulatory axis.
