Amerged presentation of clinical and radiographic data using probability plots in a clinical trial, the JESMR study
Amerged presentation of clinical and radiographic data using probability plots in a clinical trial, the JESMR study
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JESMR 研究在临床试验中使用概率图合并呈现临床和放射学数据
DOI：
10.1136/annrheumdis-2012-201804
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发表时间：
2013
期刊：
影响因子：
27.4
通讯作者：
Takeuchi T
中科院分区：
文献类型：
--
作者：
Kameda H;Kanbe K;Sato E;Ueki Y;Saito K;Nagaoka S;Hidaka T;Atsumi T;Tsukano M;Kasama T;Shiozawa S;Tanaka Y;Yamanaka H;Takeuchi T
就滑膜炎症和放射学变化（包括关节损伤修复和进展）之间的关系而言，1在类风湿性关节炎（RA）中，先前存在的关节损伤和持续性滑膜炎可能会促进关节破坏，而在没有滑膜炎的情况下，受损的关节可能会愈合。 2 3 尽管使用累积概率图呈现放射学结果大大提高了对临床试验数据的理解，4 治疗对个别 RA 患者放射学进展和改善（回归）的影响尚未得到充分解释。在 JESMR 研究中，5 6 151 名对甲氨蝶呤 (MTX) 治疗无反应的活动性 RA 患者被随机分为 2 个治疗组中的 1 个：依那西普 (ETN) 50 mg/周， 6–8 mg/周 MTX（E+ M 组），或单独 ETN（E
In terms of the relationship between synovial inflammation and radiographic changes, including both joint damage repair and progression, 1 in rheumatoid arthritis (RA), pre-existing joint damage and persistent synovitis may promote joint destruction, while in the absence of synovitis, damaged joints may heal. 2 3 Although presentation of radiographic results using cumulative probability plots has substantially improved understanding of clinical trial data, 4 the effects of treatments on radiographic progression and improvement (regression) in individual RA patients has not yet been fully explained.In the JESMR study, 5 6 151 active RA patients unresponsive to treatment with methotrexate (MTX) were randomised into 1 of 2 treatment groups: etanercept (ETN) 50 mg/week with 6–8 mg/week of MTX (the E+ M group), or ETN alone (the E