Balance point characterization of interstitial fluid volume regulation
Balance point characterization of interstitial fluid volume regulation
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DOI：
10.1152/ajpregu.00097.2009
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发表时间：
2009-07-01
影响因子：
2.8
通讯作者：
Quick, C. M.
中科院分区：
文献类型：
--
作者：
Dongaonkar, R. M.;Laine, G. A.;Quick, C. M.
Dongaonkar RM，Laine GA，Stewart RH，Quick CM.间质液容量调节的平衡点表征。Am J Physiol Regul Integr Comp Physiol 297：R6-R16，2009.首次发表于2009年5月6日; doi：10.1152/ajpregu.00097.2009。间质液容量和蛋白质调节（微血管过滤、淋巴回流和间质储存）中涉及的各个过程相对简单，但它们的相互作用极其复杂。值得注意的是，缺乏一阶代数公式，该公式将间质液压力和蛋白质与通常用于表征间质液和蛋白质运动的关键参数相关联。因此，本研究的目的是开发一种简单，透明，通用的代数方法，预测间质液压力（P-i）和蛋白质浓度（C-i），考虑到所有三个过程。同时求解表征液体和蛋白质通量的八个标准方程，以产生作为表征微血管、间质和淋巴功能的参数的函数的P-i和C-i的代数方程。P-i和C-i的平衡值作为来自经微血管和淋巴流的图形交叉点的平衡点而出现（类似于盖顿的经典心脏输出-静脉回流曲线）。这种方法通过引入流入和流出阻力的概念，超越了在质量守恒方面描述组织间液平衡。Algebrin溶液表明，P-i和C-i由微血管过滤系数（1/流入阻力）和有效淋巴阻力（流出阻力）的比值引起，Pi不受间质顺应性的影响。这些简单的代数解预测了与报告的测量结果一致的P-i和C-i。因此，目前的工作提出了一个简单的，透明的，和一般的平衡点表征间质液平衡的微血管，间质和淋巴功能的相互作用。
Dongaonkar RM, Laine GA, Stewart RH, Quick CM. Balance point characterization of interstitial fluid volume regulation. Am J Physiol Regul Integr Comp Physiol 297: R6-R16, 2009. First published May 6, 2009; doi:10.1152/ajpregu.00097.2009.-The individual processes involved in interstitial fluid volume and protein regulation (microvascular filtration, lymphatic return, and interstitial storage) are relatively simple, yet their interaction is exceedingly complex. There is a notable lack of a first-order, algebraic formula that relates interstitial fluid pressure and protein to critical parameters commonly used to characterize the movement of interstitial fluid and protein. Therefore, the purpose of the present study is to develop a simple, transparent, and general algebraic approach that predicts interstitial fluid pressure (P-i) and protein concentrations (C-i) that takes into consideration all three processes. Eight standard equations characterizing fluid and protein flux were solved simultaneously to yield algebraic equations for P-i and C-i as functions of parameters characterizing microvascular, interstitial, and lymphatic function. Equilibrium values of P-i and C-i arise as balance points from the graphical intersection of transmicrovascular and lymph flows (analogous to Guyton's classical cardiac output-venous return curves). This approach goes beyond describing interstitial fluid balance in terms of conservation of mass by introducing the concept of inflow and outflow resistances. Algebraic solutions demonstrate that P-i and C-i result from a ratio of the microvascular filtration coefficient (1/inflow resistance) and effective lymphatic resistance (outflow resistance), and Pi is unaffected by interstitial compliance. These simple algebraic solutions predict P-i and C-i that are consistent with reported measurements. The present work therefore presents a simple, transparent, and general balance point characterization of interstitial fluid balance resulting from the interaction of microvascular, interstitial, and lymphatic function.