Human renin inhibiting dipeptide.
Human renin inhibiting dipeptide.
复制标题
人肾素抑制二肽。
DOI：
10.1016/0014-2999(86)90455-3
复制
发表时间：
1986
影响因子：
5
通讯作者：
K. Iizuka
中科院分区：
文献类型：
--
作者：
N. Toda;M. Miyazaki;Y. Etoh;T. Kubota;K. Iizuka
含有非他汀的二肽KRI-1177对人和日本猴血浆肾素活性的抑制作用明显大于对狗、兔和大鼠血浆的抑制作用。通过静脉注射这种化合物，麻醉猴子的全身血压降低，同时也降低了血浆肾素活性和血管紧张素的浓度。KRI-1177似乎选择性地抑制灵长类动物肾素活性，从而产生低血压。
KRI-1177, a dipeptide containing nor-statine inhibited renin activity in human and Japanese monkey plasma to a markedly greater extent than that in dog, rabbit and rat plasma. The systematic blood pressure of anesthetized monkeys was lowered by intravenous injections of this compound which also reduced plasma renin activity and concentration of angiotensins. KRI-1177 appears to selevtively inhibit primate renin activity, thereby producing hypotension.