Development of a tissue-engineered bypass graft seeded with stem cells
Development of a tissue-engineered bypass graft seeded with stem cells
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DOI：
10.2310/6670.2006.00058
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发表时间：
2006-11-01
期刊：
影响因子：
1.1
通讯作者：
Tulenko, Thomas
中科院分区：
文献类型：
--
作者：
DiMuzio, Paul;Fischer, Lauren;Tulenko, Thomas
病变小直径动脉旁路的金标准导管仍然是自体血管组织。在没有这种组织的情况下，患者只能使用假体材料进行旁路手术，其效果远没有那么持久。血管组织工程，通过在管状支架上植入各种细胞来创造血管导管，可能为解决这一难题提供了另一种方法。在此，我们回顾了在设计理想血管导管方面仍然存在的一些重大挑战，并概述了通过将自然血管组织（脱细胞静脉异体移植物）与现成的自体细胞（脂肪来源的干细胞）相结合而产生的移植物所提供的潜在解决方案。
The gold standard conduit for bypass of diseased small-diameter arteries remains autologous vascular tissue. In the absence of such tissue, patients are offered bypass with prosthetic material, with far less durable results. Vascular tissue engineering, the creation of a vascular conduit by seeding a tubular scaffold with various cells, may offer an alternative approach to this difficult situation. Herein we review some of the significant challenges that remain in designing an ideal vascular conduit and outline potential solutions offered by a graft created by seeding natural vascular tissue (decellularized vein allograft) with readily available autologous cells (adipose-derived stem cells).