Lymphokine-activated killer cell phenomenon. III. Evidence that IL-2 is sufficient for direct activation of peripheral blood lymphocytes into lymphokine-activated killer cells.
Lymphokine-activated killer cell phenomenon. III. Evidence that IL-2 is sufficient for direct activation of peripheral blood lymphocytes into lymphokine-activated killer cells.
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DOI：
10.1084/jem.158.4.1356
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发表时间：
1983-10-01
期刊：
影响因子：
--
通讯作者：
Rosenberg SA
中科院分区：
文献类型：
--
作者：
Grimm EA;Robb RJ;Roth JA;Neckers LM;Lachman LB;Wilson DJ;Rosenberg SA
Purified interleukin 2 (IL-2) was found to be sufficient for direct activation of peripheral blood lymphocytes into lymphokine-activated killer (LAK) cells. The LAK activation factor was directly and consistently associated with IL-2 activity using classic protein purification techniques, adsorption to IL-2-dependent cell lines, and inhibition with anti-Tac antibody. As yet, no other cytokines have been found that perform the same role.
