The Role of Shape and Heart Rate on the Performance of the Left Ventricle.

The Role of Shape and Heart Rate on the Performance of the Left Ventricle.
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形状和心率对左心室性能的作用。

DOI:
10.1115/1.4031468
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发表时间:
2015
期刊:
Journal of biomechanical engineering
影响因子:
--
通讯作者:
I. Borazjani
I. Borazjani
中科院分区:
--
文献类型:
--
作者:
Zeying Song;I. Borazjani

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左心室的功能是泵送含氧血液通过循环系统。射血分数是用于检测心脏病(健康>55%)的主要非侵入性参数,并且它被认为是影响效率的主要参数。然而,其他参数对效率的影响还有待研究。我们调查的影响,心率和左心室形状进行3D数值模拟的左心室在不同的心率和扰动的几何形状下恒定的,正常的射血分数。使用浸没边界法的模拟提供了3D流场和压力场,这使得能够直接计算新的血液动力学效率(H效率)参数,该参数不依赖于任何参考压力。H效率定义为进入左心室控制容积的动能(有用功率)通量与总心脏功率的比值。我们的模拟表明,H效率对心率不敏感,但在正常心率(72 bpm)附近最大化。然而,它对左心室的形状更敏感,这在恒定射血分数下影响H效率高达15%。
The left ventricle function is to pump the oxygenated blood through the circulatory system. Ejection fraction is the main noninvasive parameter for detecting heart disease (healthy >55%), and it is thought to be the main parameter affecting efficiency. However, the effects of other parameters on efficiency have yet to be investigated. We investigate the effect of heart rate and left ventricle shape by carrying out 3D numerical simulations of a left ventricle at different heart rates and perturbed geometries under constant, normal ejection fraction. The simulation using the immersed boundary method provide the 3D flow and pressure fields, which enable direct calculation of a new hemodynamic efficiency (H-efficiency) parameter, which does not depend on any reference pressure. The H-efficiency is defined as the ratio of flux of kinetic energy (useful power) to the total cardiac power into the left ventricle control volume. Our simulations show that H-efficiency is not that sensitive to heart rate but is maximized at around normal heart rate (72 bpm). Nevertheless, it is more sensitive to the shape of the left ventricle, which affects the H-efficiency by as much as 15% under constant ejection fraction.
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