Comparison of live donor pretransplant and recipient posttransplant renal volumes.
Comparison of live donor pretransplant and recipient posttransplant renal volumes.
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活体供体移植前和受体移植后肾体积的比较。
DOI：
10.1111/ctr.12727
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
Matsuda T
中科院分区：
文献类型：
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作者：
6)Yanishi M;Kinoshita H;Yoshida T;Takayasu K;Yoshida K;Mishima T;Sugi M;Tsukaguchi H;Kawa G;Matsuda T
基于三维计算机断层扫描（3DCT）的活体供体移植前和受体移植后肾脏体积与移植后肾功能有关。我们研究了这种关联以及供体和受体之间性别/大小差异对肾脏生长速度的影响。方法回顾性分析30例活体供体移植前后3DCT检查结果。我们根据3DCT确定供体（Dvol）和受体肾体积（Rvol），并计算移植后移植物体积的变化（Vol - ratio）。我们还将Dvol除以受体体重（Dvol/RWgt），并比较了一年后体积比和Dvol/RWgt与移植后肾功能之间的相关性。我们根据供体和受体的性别确定了肾体积和肾功能的变化率。结果平均Dvol为141.7 mL， Rvol为178.4 mL。平均体积比为127.3%。Dvol/RWgt与1年后剩余肾功能呈显著线性相关（r= 0.6745, p < 0.0001）。女性供体与男性供体的组合导致肾脏体积增加最快（p < 0.001），蛋白尿水平最高（p < 0.001）。结论移植前后肾脏体积与移植后移植物功能相关，移植物生长受供体和受体相对性别的影响。
BackgroundLive donor pre‐transplant and recipient post‐transplant kidney volumes based on three‐dimensional computed tomography (3DCT) have been related to post‐transplant renal function. We examined this association and the effect of sex/size differences between donor and recipient on kidney growth rate.MethodsWe retrospectively reviewed 30 live donors who underwent pre‐transplant and post‐transplant 3DCT. We determined donor (Dvol) and recipient renal volumes (Rvol) based on 3DCT and calculated changes in graft volume after transplantation (Vol‐ratio). We also divided Dvol by recipient body weight (Dvol/RWgt) and compared the correlations between Vol‐ratio and Dvol/RWgt and post‐transplant renal function after one yr. We determined the rates of change in kidney volume and renal function according to the sexes of the donor and recipient.ResultsThe mean Dvol and Rvol were 141.7 and 178.4 mL, respectively. The mean Vol‐ratio was 127.3%. Dvol/RWgt showed a significant linear correlation with remaining renal function after one yr (r= 0.6745, p < 0.0001). The combination of female donor and male recipient resulted in the fastest increase in kidney volume (p < 0.001) and highest level of proteinuria (p < 0.001).ConclusionsPre‐transplant and post‐transplant kidney volumes are correlated with post‐transplant graft function, and graft growth is affected by the relative sexes of the recipient and donor.