Attention-related activity during episodic memory retrieval: a cross-function fMRI study
Attention-related activity during episodic memory retrieval: a cross-function fMRI study
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DOI：
10.1016/s0028-3932(02)00170-7
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发表时间：
2003-01-01
期刊：
影响因子：
2.6
通讯作者：
Nyberg, L
中科院分区：
文献类型：
--
作者：
Cabeza, R;Dolcos, F;Nyberg, L
在情景提取（ER）的功能神经影像学研究中，前额叶、顶叶、前扣带回和丘脑区域的激活通常归因于情景提取过程。然而，这些激活在视觉注意（VA）任务中也很频繁，这表明它们在ER中的作用可能反映了注意力而不是记忆过程。为了研究这种可能性，我们使用事件相关功能磁共振成像直接比较了ER和VA任务期间的大脑活动。ER任务是具有检索模式组件的单词识别测试，VA任务是具有持续注意组件的目标检测任务。这项研究得出了三个主要结论。首先，一个共同的额顶叶扣带回丘脑网络被发现ER和VA，这表明这些地区的参与ER反映了一般的注意过程。这一想法与ER文献中提出的一些解释（例如，postretrieval监测）是一致的，这些解释可以用注意过程来重新表述。第二，几个亚区差异参与ER与VA。例如，额极皮质和楔前叶的ER比VA更活跃，可能分别反映了检索模式和内部产生的刺激的处理。最后，这项研究产生了一个意想不到的发现：ER和VA的一些内侧颞叶区域被类似地激活。这一发现表明，内侧颞叶可能参与索引表征内的意识焦点，无论他们是记忆或知觉。总的来说，目前的结果表明，许多激活归因于特定的认知过程，如情节记忆，实际上可能反映了更一般的认知操作。(C)2002爱思唯尔科技有限公司版权所有。
In functional neuroimaging studies of episodic retrieval (ER), activations in prefrontal, parietal, anterior cingulate, and thalamic regions are typically attributed to episodic retrieval processes. However, these activations are also frequent during visual attention (VA) tasks, suggesting that their role in ER may reflect attentional rather than mnemonic processes. To investigate, this possibility, we directly compared brain activity during ER and VA tasks using event-related fMRI. The ER task was a word recognition test with a retrieval mode component, and the VA task was a target detection task with a sustained attention component. The study yielded three main findings. First, a common fronto-parietal-cingulate-thalamic network was found for ER and VA, suggesting that the involvement of these regions during ER reflects general attentional processes. This idea is compatible with some of the interpretations proposed in the ER literature (e.g. postretrieval monitoring), which may be rephrased in terms of attentional processes. Second, several subregions were differentially involved in ER versus VA. For example, the frontopolar cortex and the precuneus were more activated for ER than for VA, possibly reflecting retrieval mode and processing of internally generated stimuli, respectively. Finally, the study yielded an unexpected finding: some medial temporal lobe regions were similarly activated for ER and VA. This finding suggests that the medial temporal lobes may be involved in indexing representations within the focus of consciousness, regardless of whether they are mnemonic or perceptual. Overall, the present results suggest that many of the activations attributed to specific cognitive processes, such as episodic memory, may actually reflect more general cognitive operations. (C) 2002 Elsevier Science Ltd. All rights reserved.